Vacation Rentals in Pocono Medical Center, PA: Compare 10+ Sites & Save

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  2. Vacation Rentals
  3.  USA

  4.  Pennsylvania
  5.  East Stroudsburg
  6.  Pocono Medical Center

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315 Best Vacation Rentals in Pocono Medical Center (Starting from $121)

Broad Street Duplex
Broad Street Duplex
Apartment
Stroudsburg, PA, USA
1.6k from Pocono Medical Center center

Apartments, Cheap, Accommodations, Parking, Lodgings, Places to stay, Family, Self-catering

3 Bedrooms10 Guests
10.0

Exceptional

1 reviews

$315
Average price / night
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Cozy 2 Bedroom Apartment Above Local Coffee Shop in Downtown East Stroudsburg!
Cozy 2 Bedroom Apartment Above Local Coffee Shop in Downtown East Stroudsburg!
Apartment
East Stroudsburg, PA, 18301, United States
0.7k from Pocono Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, No Smoking, Patio

2 Bedrooms4 Guests
10.0

Exceptional

1 reviews

$248
Average price / night
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Prime Location on Main Street
Prime Location on Main Street
Apartment
Stroudsburg, PA, USA
1.9k from Pocono Medical Center center

Apartments, Cheap, Accommodations, Parking, Lodgings, Places to stay, Family, Self-catering, Ski resorts

3 Bedrooms10 Guests
9.5

Superb

4 reviews

$276
Average price / night
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2-bedroom apartment above coffee shop in the heart of downtown East Stroudsburg.
2-bedroom apartment above coffee shop in the heart of downtown East Stroudsburg.
Apartment
East Stroudsburg, PA, 18301, United States
1.2k from Pocono Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, No Smoking, Patio

2 Bedrooms4 Guests
10.0

Exceptional

5 reviews

$274
Average price / night
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Apt in the heart of Main Street
Apt in the heart of Main Street
Apartment
Stroudsburg, PA, USA
1.9k from Pocono Medical Center center

Apartments, Accommodations, Parking, Lodgings, Places to stay, Ski resorts

2 Bedrooms6 Guests
New to Booking
$245
Average price / night
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3-bedroom duplex apartment in lovely Stroudsburg by Main Street.
3-bedroom duplex apartment in lovely Stroudsburg by Main Street.
Apartment
Stroudsburg, PA, 18360, United States
1.3k from Pocono Medical Center center

AC, Crib, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms10 Guests
10.0

Exceptional

4 reviews

$359
Average price / night
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Walk to Main St Shops and Dining Stroudsburg Unit!
Walk to Main St Shops and Dining Stroudsburg Unit!
House
Stroudsburg, PA, USA
2.0k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$271
Average price / night
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Burntwood Cabin - Poconos
Burntwood Cabin - Poconos
House
East Stroudsburg, PA, 18301, United States
1.3k from Pocono Medical Center center

AC, Barbecue, Crib, Dryer, Free Parking, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
New to Booking
$409
Average price / night
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1 Block to Stroudsburg Main St Chic Townhome
1 Block to Stroudsburg Main St Chic Townhome
House
Stroudsburg, PA, USA
2.0k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$271
Average price / night
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Very Welcoming
Very Welcoming
House
East Stroudsburg, PA, 18301, United States
1.6k from Pocono Medical Center center

AC, Extra Bed, Fireplace, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave

3 Bedrooms6 Guests
8.0

Good

34 reviews

$207
Average price / night
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Stay and Play in Dtwn Stroudsburg Updated Townhouse
Stay and Play in Dtwn Stroudsburg Updated Townhouse
House
Stroudsburg, PA, USA
2.0k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$271
Average price / night
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Steps From Downtown Stroudsburg | 2BR + Sleeps 4
Steps From Downtown Stroudsburg | 2BR + Sleeps 4
Apartment
Stroudsburg, PA, 18360, United States
1.7k from Pocono Medical Center center

AC, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

2 Bedrooms4 Guests
10.0

Exceptional

3 reviews

$279
Average price / night
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1 Block to Main Street Dtwn Stroudsburg Townhome!
1 Block to Main Street Dtwn Stroudsburg Townhome!
House
Stroudsburg, PA, USA
2.0k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$271
Average price / night
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Elegant Historic 5BR Home in Downtown Stroudsburg
Elegant Historic 5BR Home in Downtown Stroudsburg
House
Stroudsburg, PA, 18360, United States
1.7k from Pocono Medical Center center

AC, Balcony, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

5 Bedrooms14 Guests
9.4

Superb

3 reviews

$552
Average price / night
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Shop and Dine Central Stroudsburg Townhome!
Shop and Dine Central Stroudsburg Townhome!
House
Stroudsburg, PA, USA
2.0k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$307
Average price / night
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Chic Retreat Downtown Stroudsburg | 3BR+Sleeps 10
Chic Retreat Downtown Stroudsburg | 3BR+Sleeps 10
Apartment
Stroudsburg, PA, 18360, United States
1.7k from Pocono Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, No Smoking

10.0

Exceptional

2 reviews

$294
Average price / night
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Walkable Abode in Stroudsburgs Business District!
Walkable Abode in Stroudsburgs Business District!
House
Stroudsburg, PA, USA
3.7k from Pocono Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

5 Bedrooms12 Guests
New to Booking
$337
Average price / night
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Cozy, comfortable and conveniently close to historic downtown Stroudsburg!
Cozy, comfortable and conveniently close to historic downtown Stroudsburg!
Apartment
Stroudsburg, PA, 18360, United States
1.9k from Pocono Medical Center center

Balcony, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, Toys, TV

1 Bedroom2 Guests
10.0

Exceptional

9 reviews

$121
Average price / night
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226 E Shore Dr
226 E Shore Dr
House
East Stroudsburg, PA, USA
5.7k from Pocono Medical Center center

Accommodations, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals, Places to stay, Ski resorts

4 Bedrooms8 Guests
New to Booking
$371
Average price / night
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Blue Mountain Crossing
Blue Mountain Crossing
House
Analomink, PA, USA
6.3k from Pocono Medical Center center

Barbecue/Outdoor Cooking, Security/Safety, Pool, Air Conditioner, Hot Tub, Child Friendly, Laundry

1 Bedroom10 Guests
New to Booking
$559
Average price / night
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Movie Room, Hot Tub Pocono Vacation Rental!
Movie Room, Hot Tub Pocono Vacation Rental!
House
East Stroudsburg, PA, USA
6.3k from Pocono Medical Center center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

3 Bedrooms8 Guests
9.3

Superb

3 reviews

$569
Average price / night
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Escape to Main Street
Escape to Main Street
Apartment
Stroudsburg, PA, 18360, United States
1.9k from Pocono Medical Center center

AC, Balcony, Dryer, Heater, Internet, Kitchen, Laundry, Microwave, No Smoking

5 Bedrooms16 Guests
10.0

Exceptional

1 reviews

$802
Average price / night
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Charming 4-bedroom house with AC, WiFi in brilliant Delaware Water Gap
Charming 4-bedroom house with AC, WiFi in brilliant Delaware Water Gap
House
Delaware Water Gap, PA, 18327, United States
2.4k from Pocono Medical Center center

AC, Fireplace, Free Parking, Heater, Hot Tub, Internet, Kitchen, Microwave, No Smoking

4 Bedrooms8 Guests
6.0

Review score

3 reviews

$367
Average price / night
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Charming 2-bedroom house with AC, WiFi in fantastic East Stroudsburg
Charming 2-bedroom house with AC, WiFi in fantastic East Stroudsburg
House
East Stroudsburg, PA, 18301, United States
2.6k from Pocono Medical Center center

AC, Arcade, Fireplace, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave

2 Bedrooms6 Guests
8.6

Fabulous

17 reviews

$166
Average price / night
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Delightful Vacation Home
Delightful Vacation Home
House
Stroudsburg, PA, 18360, United States
3.0k from Pocono Medical Center center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
9.0

Fabulous

2 reviews

$172
Average price / night
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A quiet mountaintop retreat with all the comforts of home!
A quiet mountaintop retreat with all the comforts of home!
House
Stroudsburg, PA, 18360, United States
3.1k from Pocono Medical Center center

AC, Fitness Equipment, Free Parking, Heater, Hot Tub, Internet, Kitchen, Living Area, Microwave

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$817
Average price / night
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Spacious Poconos Home Getaway🥂🍾🎉
Spacious Poconos Home Getaway🥂🍾🎉
House
Stroudsburg, PA, 18360, United States
3.4k from Pocono Medical Center center

AC, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Hot Tub, Internet, Laundry

4 Bedrooms10 Guests
New to Booking
$337
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Pocono Medical Center.

Pocono Medical Center Vacation Rentals on the Map

Frequently Asked Questions

You can explore 315 verified vacation rentals in Pocono Medical Center. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Pocono Medical Center vary depending on the season, property size, and location. Rates typically start from around $121 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Pocono Medical Center include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Pocono Medical Center welcome pets. Currently, 59 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Pocono Medical Center often include amenities such as Fireplace/Heating, Internet, and Balcony/Terrace. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.