Vacation Rentals in Midtown, MO: Compare 10+ Sites & Save

AirbnbBooking.comVrboExpediaKayakTripadvisorHotels.comAgoda.com
  1. VBOR
  2. Vacation Rentals
  3.  USA

  4.  Missouri

  5.  St. Louis
  6.  Midtown

Refine your search

Price per night

Amenity Filter

Rating

1045 Best Vacation Rentals in Midtown (Starting from $95)

City House
City House
House
Midtown, St. Louis, Missouri, USA
0.8k from Midtown center

Internet, Wheelchair Accessible, Pet Friendly, Parking, Air Conditioner, Child Friendly

4 Bedrooms10 Guests
New to Booking
$8050
Average price / night
Check Availability
Travel nurse dream
Travel nurse dream
Apartment
St. Louis, MO, 63103, United States
0.4k from Midtown center

AC, Dryer, Internet, Laundry, No Smoking, TV, Washer

1 Bedroom2 Guests
New to Booking
$100
Average price / night
Check Availability
Uptown Elegant Escape | JZ Vacation Rentals
Uptown Elegant Escape | JZ Vacation Rentals
House
Tower Grove, MO, USA
1.2k from Midtown center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

5 Bedrooms15 Guests
New to Booking
$378
Average price / night
Check Availability
Stylish Loft in St. Louis with Gym, Rooftop, Free Gated Parking, and Pool
Stylish Loft in St. Louis with Gym, Rooftop, Free Gated Parking, and Pool
Apartment
St. Louis, MO, 63103, United States
1.0k from Midtown center

AC, Balcony, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms5 Guests
New to Booking
$233
Average price / night
Check Availability
Bright Urban Comfort | JZ Vacation Rentals
Bright Urban Comfort | JZ Vacation Rentals
House
Tower Grove, MO, USA
1.2k from Midtown center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

5 Bedrooms14 Guests
New to Booking
$358
Average price / night
Check Availability
Artsy Creative Haven Home St. Louis Art District
Artsy Creative Haven Home St. Louis Art District
House
St. Louis, MO, 63113, United States
1.1k from Midtown center

AC, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms11 Guests
9.6

Exceptional

10 reviews

$393
Average price / night
Check Availability
3323 Uptown Elegant Escape
3323 Uptown Elegant Escape
House
Tower Grove, MO, USA
1.2k from Midtown center

Accommodations, Villas, Vacation homes, Cottages, Lodgings, Places to stay

1 Bedroom15 Guests
New to Booking
$774
Average price / night
Check Availability
Charming 1-Bedroom, 1-Bathroom Loft in St. Louis with a Terrace, Rooftop, Gym
Charming 1-Bedroom, 1-Bathroom Loft in St. Louis with a Terrace, Rooftop, Gym
Apartment
St. Louis, MO, 63103, United States
1.1k from Midtown center

AC, Balcony, Barbecue, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

1 Bedroom4 Guests
New to Booking
$142
Average price / night
Check Availability
3325 Bright Urban Comfort
3325 Bright Urban Comfort
House
Tower Grove, MO, USA
1.2k from Midtown center

Accommodations, Villas, Vacation homes, Cottages, Lodgings, Places to stay

1 Bedroom14 Guests
New to Booking
$736
Average price / night
Check Availability
Spacious 5-bedroom house in Downtown Saint Louis with free Parking and Yard.
Spacious 5-bedroom house in Downtown Saint Louis with free Parking and Yard.
House
St. Louis, MO, 63104, United States
1.1k from Midtown center

AC, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

5 Bedrooms14 Guests
10.0

Exceptional

1 reviews

$497
Average price / night
Check Availability
WhiteHouse at Grand Central
WhiteHouse at Grand Central
Apartment
Tower Grove, MO, USA
1.2k from Midtown center

Apartments, Accommodations, Parking, Pet-friendly, Lodgings, Vacation rentals, Places to stay, Self-catering

12 Bedrooms24 Guests
7.7

Good

163 reviews

$114
Average price / night
Check Availability
Grand Center Inn
Grand Center Inn
House
3716 Grandel Square, St. Louis, MO, 63108, United States
1.1k from Midtown center

AC, Business Services, Fireplace, Free Parking, Heater, Internet, Microwave, No Smoking, Outdoor Space

9.4

Superb

82 reviews

$194
Average price / night
Check Availability
Modern Escape: 5BR/2.5BA Near St. Louis Must-Sees
Modern Escape: 5BR/2.5BA Near St. Louis Must-Sees
House
Saint Louis, MO, USA
1.3k from Midtown center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Self-catering

5 Bedrooms12 Guests
9.0

Fabulous

1 reviews

$664
Average price / night
Check Availability
Rustic Charm 4BDRM Home| STL Developers
Rustic Charm 4BDRM Home| STL Developers
House
St. Louis, MO, 63104, United States
1.1k from Midtown center

AC, Balcony, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms8 Guests
9.4

Superb

55 reviews

$219
Average price / night
Check Availability
Modern 1BR-1BA Walk to SSM SLU Hospital Grand
Modern 1BR-1BA Walk to SSM SLU Hospital Grand
Apartment
Tower Grove, MO, USA
1.5k from Midtown center

Apartments, Cheap, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

1 Bedroom3 Guests
8.0

Good

4 reviews

$112
Average price / night
Check Availability
Entire 4BR Home near Lafayette Square
Entire 4BR Home near Lafayette Square
House
St. Louis, MO, 63104, United States
1.1k from Midtown center

AC, Barbecue, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms8 Guests
9.8

Exceptional

96 reviews

$244
Average price / night
Check Availability
Chic Studio Walk to SMM SLU Hospital Grand
Chic Studio Walk to SMM SLU Hospital Grand
Apartment
Tower Grove, MO, USA
1.5k from Midtown center

Apartments, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

1 Bedroom3 Guests
7.6

Good

15 reviews

$95
Average price / night
Check Availability
Spacious 5BR Home | Amazing Shower | Near SLU & Tower Grove | The Gate STL
Spacious 5BR Home | Amazing Shower | Near SLU & Tower Grove | The Gate STL
House
St Louis, MO, 63104, United States
1.2k from Midtown center

AC, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet, Kitchen, Laundry

5 Bedrooms14 Guests
9.4

Superb

6 reviews

$607
Average price / night
Check Availability
Perfect Getaway at CWE- Entire Home with Free Parking Near Fox, Universities and More!
Perfect Getaway at CWE- Entire Home with Free Parking Near Fox, Universities and More!
House
Saint Louis, MO, USA
1.5k from Midtown center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

3 Bedrooms6 Guests
New to Booking
$597
Average price / night
Check Availability
Spacious 5BR Near SLU | Drive to Arch, Ballparks & Breweries | EV Charger
Spacious 5BR Near SLU | Drive to Arch, Ballparks & Breweries | EV Charger
House
St Louis, MO, 63104, United States
1.2k from Midtown center

AC, Dryer, Extra Bed, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

5 Bedrooms15 Guests
9.8

Exceptional

13 reviews

$685
Average price / night
Check Availability
Modern Home w/Garage Near SLU | JZ Vacation Rentals
Modern Home w/Garage Near SLU | JZ Vacation Rentals
House
Soulard, MO, USA
1.5k from Midtown center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

4 Bedrooms10 Guests
New to Booking
$385
Average price / night
Check Availability
Zen Cottage w/ Private Parking / ABODEbucks
Zen Cottage w/ Private Parking / ABODEbucks
House
St. Louis, MO, 63104-1831, United States
1.2k from Midtown center

AC, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave

4 Bedrooms10 Guests
9.2

Superb

11 reviews

$498
Average price / night
Check Availability
Chic 1/1 apartment in Historic area, near SLU, CWE, and Grand Center-Apt G
Chic 1/1 apartment in Historic area, near SLU, CWE, and Grand Center-Apt G
Apartment
St. Louis, MO, 63108, United States
1.2k from Midtown center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry

1 Bedroom2 Guests
10.0

Exceptional

1 reviews

$177
Average price / night
Check Availability
Modern Studio SLU, Fox Thtr, CWE-Apt J
Modern Studio SLU, Fox Thtr, CWE-Apt J
Apartment
St. Louis, MO, 63108, United States
1.2k from Midtown center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry

1 Bedroom2 Guests
New to Booking
$227
Average price / night
Check Availability
Sleek & Central Studio by SLU
Sleek & Central Studio by SLU
Apartment
St. Louis, MO, 63108, United States
1.2k from Midtown center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry

1 Bedroom2 Guests
10.0

Exceptional

2 reviews

$172
Average price / night
Check Availability
Historic Gem by SLU 1Bed/1Bath Apt-B
Historic Gem by SLU 1Bed/1Bath Apt-B
Apartment
St. Louis, MO, 63108, United States
1.2k from Midtown center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry

1 Bedroom2 Guests
6.0

Review score

1 reviews

$173
Average price / night
Check Availability
Charming Historic Apt near SLU - Apt C
Charming Historic Apt near SLU - Apt C
Apartment
St. Louis, MO, 63108, United States
1.2k from Midtown center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry

1 Bedroom2 Guests
9.0

Fabulous

2 reviews

$174
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Midtown.

Where to stay in Midtown? Best neighborhoods & areas

Stay Near Midtown's Top Attractions

VacationByOwnerRentals can help you find hotels, resorts, and rentals near many of 's top attractions, neighborhoods, and points of interest.

Midtown Vacation Rentals on the Map

Frequently Asked Questions

You can explore 1045 verified vacation rentals in Midtown. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Midtown vary depending on the season, property size, and location. Rates typically start from around $95 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Midtown include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Midtown welcome pets. Currently, 54 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Midtown often include amenities such as Fireplace/Heating, Laundry, and Guest Services. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.