Vacation Rentals in Melrose, FL: Compare 10+ Sites & Save

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55 Best Vacation Rentals in Melrose (Starting from $69)

Unique Melrose Home with Private Dock and Lake Access!
Unique Melrose Home with Private Dock and Lake Access!
House
Keystone Heights, FL, USA
1.8k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay, Family

3 Bedrooms8 Guests
6.0

Review score

1 reviews

$442
Average price / night
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Estate Home on beautiful Melrose Bay
Estate Home on beautiful Melrose Bay
House
Melrose, FL, 32666, United States
0.5k from Melrose center

AC, Balcony, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms7 Guests
9.8

Exceptional

36 reviews

$414
Average price / night
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Remodeled Lakefront Home Boat Docks and Ramp!
Remodeled Lakefront Home Boat Docks and Ramp!
House
Melrose, Florida, USA
3.9k from Melrose center

Wheelchair Accessible, Parking, Pet Friendly, Internet, Child Friendly

3 Bedrooms8 Guests
New to Booking
$212
Average price / night
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Modern LAKE HOUSE on Lake Santa Fe near Gville/UF
Modern LAKE HOUSE on Lake Santa Fe near Gville/UF
House
Melrose, FL, 32666, United States
1.5k from Melrose center

AC, Arcade, Barbecue, Dryer, Heater, Internet, Kitchen, Laundry, Microwave

3 Bedrooms8 Guests
10.0

Exceptional

6 reviews

$598
Average price / night
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Home on Lake Hutchinson with Dock!
Home on Lake Hutchinson with Dock!
House
Keystone Heights, FL, USA
5.2k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

4 Bedrooms10 Guests
New to Booking
$399
Average price / night
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Unique Melrose Home w/ Private Dock & Lake Access!
Unique Melrose Home w/ Private Dock & Lake Access!
House
Melrose, FL, 32666, United States
1.8k from Melrose center

AC, Arcade, Barbecue, Dryer, Extra Bed, Fireplace, Free Parking, Heater, Internet

3 Bedrooms6 Guests
9.2

Superb

12 reviews

$336
Average price / night
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Lake Winnott Home with Boat Ramp and Dock
Lake Winnott Home with Boat Ramp and Dock
House
Hawthorne, FL, USA
6.4k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

6 Bedrooms20 Guests
New to Booking
$450
Average price / night
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Lakefront Haven w/ Pool!
Lakefront Haven w/ Pool!
House
Melrose, FL, 32666, United States
1.9k from Melrose center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

4 Bedrooms8 Guests
10.0

Exceptional

11 reviews

$415
Average price / night
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Hawthorne Retreat with Casita and Lake Winnott Access!
Hawthorne Retreat with Casita and Lake Winnott Access!
House
Hawthorne, FL, USA
6.8k from Melrose center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals

3 Bedrooms12 Guests
9.0

Fabulous

2 reviews

$165
Average price / night
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FISH from dock/ Covered boat slip- on Canal to Lake Santa Fe
FISH from dock/ Covered boat slip- on Canal to Lake Santa Fe
House
Melrose, FL, 32666, United States
2.2k from Melrose center

AC, Barbecue, Dryer, Extra Bed, Free Parking, Heater, Kitchen, Laundry, Living Area

2 Bedrooms6 Guests
8.6

Fabulous

4 reviews

$188
Average price / night
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Half Moon Lake property
Half Moon Lake property
House
Melrose, FL, USA
6.9k from Melrose center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom3 Guests
9.4

Superb

5 reviews

$98
Average price / night
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House in Melrose on Lake Sante Fe
House in Melrose on Lake Sante Fe
House
Melrose, FL, 32666, United States
3.2k from Melrose center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms14 Guests
10.0

Exceptional

13 reviews

$595
Average price / night
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Lakefront Keystone Heights Home with Boat Dock!
Lakefront Keystone Heights Home with Boat Dock!
House
Keystone Heights, FL, USA
7.0k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

3 Bedrooms8 Guests
1.0

Review score

1 reviews

$204
Average price / night
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Rustic Fishing Cabin on Lake Swan, Melrose
Rustic Fishing Cabin on Lake Swan, Melrose
Cabin
Melrose, FL, 32666, United States
3.3k from Melrose center

AC, Barbecue, Dryer, Extra Bed, Fireplace, Free Parking, Heater, Internet, Kitchen

3 Bedrooms4 Guests
10.0

Exceptional

29 reviews

$171
Average price / night
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SPACIOUS POOL HOME in North FL
SPACIOUS POOL HOME in North FL
House
Keystone Heights, FL, USA
7.8k from Melrose center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly

3 Bedrooms7 Guests
7.1

Good

40 reviews

$69
Average price / night
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Cozy Lakeside Cabin in Melrose
Cozy Lakeside Cabin in Melrose
House
Melrose, FL, 32666, United States
3.6k from Melrose center

AC, Arcade, Dryer, Heater, Internet, Kitchen, Laundry, No Smoking, Washer

3 Bedrooms8 Guests
10.0

Exceptional

6 reviews

$304
Average price / night
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20 Mi to UF Campus Santa Fe Lake Escape with Dock!
20 Mi to UF Campus Santa Fe Lake Escape with Dock!
House
Waldo, FL, USA
7.9k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay, Family

5 Bedrooms10 Guests
New to Booking
$370
Average price / night
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Book your escape to paradise at The Lake Cottage at Santa Fe!
Book your escape to paradise at The Lake Cottage at Santa Fe!
House
Melrose, FL, 32666, United States
3.7k from Melrose center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Internet, Kitchen, Laundry

3 Bedrooms8 Guests
10.0

Exceptional

12 reviews

$410
Average price / night
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Charming Waldo Getaway Near Lake Santa Fe!
Charming Waldo Getaway Near Lake Santa Fe!
House
Waldo, FL, USA
7.9k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay, Family

3 Bedrooms8 Guests
10.0

Exceptional

4 reviews

$164
Average price / night
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Santa Fe Lake Front with Canal for your Boat
Santa Fe Lake Front with Canal for your Boat
House
Melrose, FL, 32666, United States
3.9k from Melrose center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Laundry, Microwave, TV

3 Bedrooms8 Guests
10.0

Exceptional

2 reviews

$309
Average price / night
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Hawthorne Vacation Rental with Access to Cue Lake
Hawthorne Vacation Rental with Access to Cue Lake
House
Interlachen, FL, USA
9.1k from Melrose center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay

3 Bedrooms9 Guests
7.0

Good

1 reviews

$295
Average price / night
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*Lakefront Retreat*- Lake/Private
*Lakefront Retreat*- Lake/Private
House
Melrose, FL, 32666, United States
3.9k from Melrose center

AC, Balcony, Dryer, Extra Bed, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms8 Guests
9.4

Superb

20 reviews

$217
Average price / night
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Lake living close to Gainesville, UF Health and University of Florida
Lake living close to Gainesville, UF Health and University of Florida
House
Melrose, FL, 32666, United States
4.0k from Melrose center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms7 Guests
9.8

Exceptional

100 reviews

$270
Average price / night
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The Nest on Lake Santa Fe in Melrose, FL
The Nest on Lake Santa Fe in Melrose, FL
Cottage
Melrose, FL, 32666, United States
4.0k from Melrose center

AC, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
10.0

Exceptional

29 reviews

$195
Average price / night
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Escape to Beautiful Lake Lily
Escape to Beautiful Lake Lily
House
Melrose, FL, 32666, United States
4.1k from Melrose center

AC, Barbecue, Dryer, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
10.0

Exceptional

6 reviews

$312
Average price / night
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Lily Pad Lake Cottage-Spring has arrived! 2/2 ,King,Hot tub, Firepit,Boats,Fish
Lily Pad Lake Cottage-Spring has arrived! 2/2 ,King,Hot tub, Firepit,Boats,Fish
Cottage
MELROSE, FL, FL, 32666, United States
4.4k from Melrose center

AC, Barbecue, Breakfast Available, Crib, Dryer, Fireplace, Free Parking, Heater, Hot Tub

2 Bedrooms4 Guests
10.0

Exceptional

4 reviews

$225
Average price / night
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Sandy Toes Bungalow-2/2 Warm & Sunny Lake Vaca, Lakeview/Access, Firepit,Hot tub
Sandy Toes Bungalow-2/2 Warm & Sunny Lake Vaca, Lakeview/Access, Firepit,Hot tub
House
Melrose, FL, 32666, United States
4.5k from Melrose center

AC, Barbecue, Breakfast Available, Crib, Dryer, Fireplace, Free Parking, Heater, Hot Tub

2 Bedrooms5 Guests
9.6

Exceptional

5 reviews

$221
Average price / night
Check Availability

Other accommodation types in Melrose:

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Melrose.

Melrose Vacation Rentals on the Map

Frequently Asked Questions

You can explore 55 verified vacation rentals in Melrose. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Melrose vary depending on the season, property size, and location. Rates typically start from around $69 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Melrose include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Melrose welcome pets. Currently, 28 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Melrose often include amenities such as Fireplace/Heating, Pet Friendly, and Internet. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.