Vacation Rentals in Mayo Clinic Scottsdale, AZ: Compare 10+ Sites & Save

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689 Best Vacation Rentals in Mayo Clinic Scottsdale (Starting from $65)

Pool Access, Views Scottsdale Serenity Condo!
Pool Access, Views Scottsdale Serenity Condo!
Apartment
Scottsdale, AZ, USA
0.6k from Mayo Clinic Scottsdale center

Apartments, Accommodations, Parking, Spa, Lodgings, Vacation rentals, Hot tubs, Places to stay, Condos

1 Bedroom2 Guests
New to Booking
$121
Average price / night
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Desert Retreat - 4BR/3BA Heated Pool & Spa - Recently Renovated - Monthly Rental
Desert Retreat - 4BR/3BA Heated Pool & Spa - Recently Renovated - Monthly Rental
House
Scottsdale, AZ, 85259, United States
0.6k from Mayo Clinic Scottsdale center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet

4 Bedrooms8 Guests
10.0

Exceptional

132 reviews

$65
Average price / night
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Elegant Scottsdale Desert Retreat with Private Pool, Hot Tub, Game Room, and Family-Friendly Amenities
Elegant Scottsdale Desert Retreat with Private Pool, Hot Tub, Game Room, and Family-Friendly Amenities
House
Scottsdale, AZ, USA
0.7k from Mayo Clinic Scottsdale center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

5 Bedrooms13 Guests
10.0

Exceptional

1 reviews

$666
Average price / night
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Peaceful & serene ~ Private home close to Mayo Clinic
Peaceful & serene ~ Private home close to Mayo Clinic
House
Scottsdale, AZ, 85259, United States
0.6k from Mayo Clinic Scottsdale center

AC, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms6 Guests
9.2

Superb

11 reviews

$372
Average price / night
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Luxury Mountain Estate-Pool-Spa-BBQ+Bar-Fire pit
Luxury Mountain Estate-Pool-Spa-BBQ+Bar-Fire pit
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Luxury, Accommodations, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

6 Bedrooms14 Guests
New to Booking
$2739
Average price / night
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Luxury Single Story Home w/ Pool House, Heated Pool/Spa, Outdoor Living, Fire Pit, Garage Parking!
Luxury Single Story Home w/ Pool House, Heated Pool/Spa, Outdoor Living, Fire Pit, Garage Parking!
House
Scottsdale, AZ, 85259, United States
0.9k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Hot Tub, Internet

5 Bedrooms13 Guests
10.0

Exceptional

18 reviews

$738
Average price / night
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NEW Gold Dust Private Villa
NEW Gold Dust Private Villa
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$911
Average price / night
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North Scottsdale Sanctuary w/ Htd Pool and Views!
North Scottsdale Sanctuary w/ Htd Pool and Views!
House
Scottsdale, AZ, 85259, United States
0.9k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Heater, Internet, Kitchen, Laundry, Living Area

4 Bedrooms8 Guests
New to Booking
$259
Average price / night
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Luxe Scottsdale Home with Pool and Mountain Views!
Luxe Scottsdale Home with Pool and Mountain Views!
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings

6 Bedrooms15 Guests
10.0

Exceptional

1 reviews

$977
Average price / night
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Private Pool • Dog Friendly • Movie Room • Games
Private Pool • Dog Friendly • Movie Room • Games
House
Scottsdale, AZ, 85259, United States
1.0k from Mayo Clinic Scottsdale center

AC, Arcade, Balcony, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet

5 Bedrooms14 Guests
New to Booking
$565
Average price / night
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Midnight At The Oasis
Midnight At The Oasis
House
Scottsdale, AZ, USA
1.2k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Lodgings, Places to stay

7 Bedrooms16 Guests
New to Booking
$1637
Average price / night
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Prime Location, Heated Saltwater Pool, Access to Tennis Courts, BBQ, and More!
Prime Location, Heated Saltwater Pool, Access to Tennis Courts, BBQ, and More!
House
Scottsdale, AZ, 85259, United States
1.0k from Mayo Clinic Scottsdale center

AC, Barbecue, Breakfast Available, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet

3 Bedrooms6 Guests
New to Booking
$229
Average price / night
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Arcadia by AvantStay Breathtaking Oasis in Scottsdale w Pool Hot Tub Game Room
Arcadia by AvantStay Breathtaking Oasis in Scottsdale w Pool Hot Tub Game Room
Villa
Scottsdale, AZ, USA
1.3k from Mayo Clinic Scottsdale center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

4 Bedrooms10 Guests
10.0

Exceptional

1 reviews

$483
Average price / night
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Luxury 5200sf/1 acre Desert Villa w pool/spa/mountain views
Luxury 5200sf/1 acre Desert Villa w pool/spa/mountain views
Villa
Scottsdale, AZ, 85259, United States
1.0k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater

5 Bedrooms16 Guests
10.0

Exceptional

37 reviews

$1208
Average price / night
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The Scottsdale Haven w Heated Pool, 7 bed & 7 bath
The Scottsdale Haven w Heated Pool, 7 bed & 7 bath
House
Scottsdale, AZ, USA
2.0k from Mayo Clinic Scottsdale center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom14 Guests
New to Booking
$2025
Average price / night
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Private Scottsdale Estate | Pool , Spa & Views
Private Scottsdale Estate | Pool , Spa & Views
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater

5 Bedrooms10 Guests
9.6

Exceptional

4 reviews

$881
Average price / night
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Luxury Estate, Heated Pool, Pickleball Court, More
Luxury Estate, Heated Pool, Pickleball Court, More
Villa
Scottsdale, AZ, USA
2.1k from Mayo Clinic Scottsdale center

Luxury, Accommodations, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings

6 Bedrooms12 Guests
New to Booking
$1586
Average price / night
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Luxe Resort | Heated Pool+Spa | 5 Bedrooms
Luxe Resort | Heated Pool+Spa | 5 Bedrooms
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Balcony, Barbecue, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater

5 Bedrooms14 Guests
10.0

Exceptional

1 reviews

$829
Average price / night
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Desert Retreat
Desert Retreat
House
Scottsdale, AZ, USA
2.4k from Mayo Clinic Scottsdale center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

1 Bedroom14 Guests
New to Booking
$823
Average price / night
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Inviting townhouse with pool, hot tub, balcony, central AC, & W/D
Inviting townhouse with pool, hot tub, balcony, central AC, & W/D
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Balcony, Barbecue, Dryer, Elevator, Fireplace, Free Parking, Heater, Hot Tub

3 Bedrooms6 Guests
New to Booking
$223
Average price / night
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Pickleball Cornhole Basketball Court Tons of space at Paradise Heights Retreat
Pickleball Cornhole Basketball Court Tons of space at Paradise Heights Retreat
House
Scottsdale, AZ, USA
2.7k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Hot tubs

5 Bedrooms14 Guests
New to Booking
$805
Average price / night
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Magnificent Mountainside Estate with Ultimate Privacy
Magnificent Mountainside Estate with Ultimate Privacy
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Balcony, Barbecue, Business Services, Crib, Dryer, Fireplace, Fitness Equipment

8 Bedrooms18 Guests
9.6

Exceptional

17 reviews

$2377
Average price / night
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5 bd Luxury Oasis Heated Pool Spa Pickle Ball
5 bd Luxury Oasis Heated Pool Spa Pickle Ball
Apartment
Scottsdale, AZ, USA
3.3k from Mayo Clinic Scottsdale center

Apartments, Luxury, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

5 Bedrooms12 Guests
New to Booking
$732
Average price / night
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7 bed Scottsdale Villa Heated Pool and Spa Golf
7 bed Scottsdale Villa Heated Pool and Spa Golf
Apartment
Scottsdale, AZ, USA
3.4k from Mayo Clinic Scottsdale center

Apartments, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

4 Bedrooms16 Guests
New to Booking
$650
Average price / night
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Luxe Scottsdale Home w/ Pool & Mountain Views!
Luxe Scottsdale Home w/ Pool & Mountain Views!
House
Scottsdale, AZ, 85259-3531, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Kitchen

6 Bedrooms15 Guests
9.6

Exceptional

27 reviews

$608
Average price / night
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Scottsdale Sunset Retreat | Patio, Spa  & Views
Scottsdale Sunset Retreat | Patio, Spa & Views
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Balcony, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Hot Tub

4 Bedrooms8 Guests
9.0

Fabulous

2 reviews

$554
Average price / night
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Private Pickleball Court Mountain Views Oasis
Private Pickleball Court Mountain Views Oasis
House
Scottsdale, AZ, 85259, United States
1.2k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Dryer, Free Parking, Hot Tub, Internet, Kitchen, Laundry

6 Bedrooms16 Guests
9.4

Superb

3 reviews

$741
Average price / night
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Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Mayo Clinic Scottsdale.

Where to stay in Mayo Clinic Scottsdale? Best neighborhoods & areas

Mayo Clinic Scottsdale Vacation Rentals on the Map

Frequently Asked Questions

You can explore 689 verified vacation rentals in Mayo Clinic Scottsdale. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Mayo Clinic Scottsdale vary depending on the season, property size, and location. Rates typically start from around $65 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Mayo Clinic Scottsdale include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Mayo Clinic Scottsdale welcome pets. Currently, 43 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Mayo Clinic Scottsdale often include amenities such as Pool, Fireplace/Heating, and Wellness Facilities. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.