Vacation Rentals in Isle of Palms, FL: Compare 10+ Sites & Save

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  4.  Florida
  5.  Jacksonville
  6.  Isle of Palms

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963 Best Vacation Rentals in Isle of Palms (Starting from $153)

New Mins to Mayo Clinic Peaceful water views
New Mins to Mayo Clinic Peaceful water views
House
Jacksonville, FL, USA
0.4k from Isle of Palms center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

4 Bedrooms8 Guests
New to Booking
$173
Average price / night
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Seabreeze Boating Way|Pool| Dock
Seabreeze Boating Way|Pool| Dock
House
Jacksonville, FL, 32250, United States
0.2k from Isle of Palms center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Living Area

2 Bedrooms4 Guests
New to Booking
$466
Average price / night
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Canal-Front Retreat 4 Mi to Jacksonville Beach!
Canal-Front Retreat 4 Mi to Jacksonville Beach!
House
Jacksonville, FL, USA
0.4k from Isle of Palms center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$329
Average price / night
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Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
House
Jacksonville, FL, 32250, United States
0.3k from Isle of Palms center

AC, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

4 Bedrooms8 Guests
9.4

Superb

78 reviews

$312
Average price / night
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Palm Escape
Palm Escape
House
Jacksonville, FL, USA
0.5k from Isle of Palms center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

2 Bedrooms10 Guests
New to Booking
$811
Average price / night
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Mayo Clinic 1.8 miles #2 Your Home Away From Home
Mayo Clinic 1.8 miles #2 Your Home Away From Home
House
Jacksonville Beach, FL, 32250, United States
0.3k from Isle of Palms center

AC, Dryer, Free Parking, Heater, Internet, Laundry, No Smoking, Washer

3 Bedrooms5 Guests
9.6

Exceptional

8 reviews

$367
Average price / night
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5 Star Ultimate King Suite near Mayo
5 Star Ultimate King Suite near Mayo
Apartment
Jacksonville, FL, USA
1.2k from Isle of Palms center

Parking, Wheelchair Accessible, Balcony/Terrace, Hot Tub, Internet, Air Conditioner, Pool

2 Bedrooms4 Guests
New to Booking
$187
Average price / night
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Be A Nomad - Close to Mayo & Beaches
Be A Nomad - Close to Mayo & Beaches
Apartment
FL, USA
1.8k from Isle of Palms center

Apartments, Accommodations, Parking, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$219
Average price / night
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Private Pool Getaway • 5min Beach • Sleeps 9
Private Pool Getaway • 5min Beach • Sleeps 9
House
Jacksonville, FL, 32250, United States
0.4k from Isle of Palms center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, No Smoking, Outdoor Space

4 Bedrooms9 Guests
10.0

Exceptional

2 reviews

$506
Average price / night
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Be A Nomad - Spacious Home close to Mayo & Beaches
Be A Nomad - Spacious Home close to Mayo & Beaches
Apartment
Jacksonville, FL, USA
1.8k from Isle of Palms center

Apartments, Accommodations, Parking, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$627
Average price / night
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Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
House
Jacksonville, FL, 32250, United States
0.4k from Isle of Palms center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms6 Guests
8.8

Fabulous

5 reviews

$353
Average price / night
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Courtney Woods Oasis by SkyRun Jacksonville
Courtney Woods Oasis by SkyRun Jacksonville
House
Isle of Palms South, FL, USA
2.2k from Isle of Palms center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom6 Guests
New to Booking
$282
Average price / night
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Lux Pool Home Close to Mayo & Jacksonville Beach!
Lux Pool Home Close to Mayo & Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
0.4k from Isle of Palms center

AC, Dryer, Heater, Internet, Kitchen, Laundry, No Smoking, Pool, TV

3 Bedrooms6 Guests
10.0

Exceptional

9 reviews

$349
Average price / night
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Jacksonville Home, Near Beach and Mayo Clinic!
Jacksonville Home, Near Beach and Mayo Clinic!
House
Jacksonville, FL, USA
2.3k from Isle of Palms center

Internet, Parking, Pet Friendly, Wheelchair Accessible, Pool, Child Friendly

3 Bedrooms6 Guests
New to Booking
$387
Average price / night
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Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
House
Jacksonville, FL, 32250, United States
0.4k from Isle of Palms center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
9.8

Exceptional

38 reviews

$320
Average price / night
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Beach Retreat in Jacksonville PetandFamily-Friendly
Beach Retreat in Jacksonville PetandFamily-Friendly
House
Jacksonville Beach, FL, USA
2.5k from Isle of Palms center

Accommodations, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings, Vacation rentals

4 Bedrooms12 Guests
7.5

Good

4 reviews

$813
Average price / night
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5 min to Mayo—luxury, comfort & care designed for patients & caregivers.
5 min to Mayo—luxury, comfort & care designed for patients & caregivers.
House
Jacksonville Beach, FL, 32250, United States
0.5k from Isle of Palms center

AC, Barbecue, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Living Area, Microwave

3 Bedrooms8 Guests
10.0

Exceptional

1 reviews

$707
Average price / night
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Taj Duval, Sleeps 14, Pool, Lux
Taj Duval, Sleeps 14, Pool, Lux
House
Jacksonville Beach, FL, USA
2.6k from Isle of Palms center

Accommodations, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings, Places to stay, Family

5 Bedrooms14 Guests
New to Booking
$1852
Average price / night
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SMV Palm Escape Retreat nr Mayo
SMV Palm Escape Retreat nr Mayo
House
Jacksonville, FL, 32250, United States
0.5k from Isle of Palms center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
10.0

Exceptional

2 reviews

$648
Average price / night
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Condo near Jax Beach and Mayo Clinic
Condo near Jax Beach and Mayo Clinic
Apartment
FL, USA
2.9k from Isle of Palms center

Apartments, Cheap, Accommodations, Pools, Parking, Lodgings, Hot tubs, Places to stay, Family

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$153
Average price / night
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 Saltwater Pool I Firepits I Large Fenced Backyard I 4 Miles to Beach
Saltwater Pool I Firepits I Large Fenced Backyard I 4 Miles to Beach
House
Jacksonville, FL, 32250, United States
0.6k from Isle of Palms center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
9.8

Exceptional

14 reviews

$386
Average price / night
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Great Condo near Beaches and Mayo Clinic
Great Condo near Beaches and Mayo Clinic
Apartment
Jacksonville, FL, USA
2.9k from Isle of Palms center

Apartments, Accommodations, Parking, Lodgings, Places to stay, Condos

3 Bedrooms6 Guests
New to Booking
$279
Average price / night
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New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach
New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach
House
Jacksonville, FL, 32250, United States
0.6k from Isle of Palms center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, No Smoking

4 Bedrooms8 Guests
10.0

Exceptional

11 reviews

$629
Average price / night
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Reel Relaxed | Team Joseph Ellen
Reel Relaxed | Team Joseph Ellen
House
Jacksonville Beach, FL, 32250, United States
0.6k from Isle of Palms center

AC, Balcony, Barbecue, Dryer, Heater, Hot Tub, Internet, Kitchen, Microwave

3 Bedrooms8 Guests
New to Booking
$443
Average price / night
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North Star Hideaway - Discover a hidden gem close to Jacksonville Beach, FL.
North Star Hideaway - Discover a hidden gem close to Jacksonville Beach, FL.
House
Jacksonville, FL, 32250, United States
0.6k from Isle of Palms center

AC, Dryer, Heater, Laundry, No Smoking, Washer

4 Bedrooms8 Guests
New to Booking
$299
Average price / night
Check Availability
Family-Friendly Jax Beach Retreat with Heated Pool
Family-Friendly Jax Beach Retreat with Heated Pool
House
Jacksonville Beach, FL, 32250, United States
0.6k from Isle of Palms center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet

4 Bedrooms8 Guests
10.0

Exceptional

36 reviews

$495
Average price / night
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Tres Palmas!Renovated Pool Home Near Mayo & Beach!
Tres Palmas!Renovated Pool Home Near Mayo & Beach!
House
Jacksonville, FL, 32250, United States
0.7k from Isle of Palms center

AC, Balcony, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms6 Guests
9.8

Exceptional

12 reviews

$620
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Isle of Palms.

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Frequently Asked Questions

You can explore 963 verified vacation rentals in Isle of Palms. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Isle of Palms vary depending on the season, property size, and location. Rates typically start from around $153 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Isle of Palms include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Isle of Palms welcome pets. Currently, 52 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Isle of Palms often include amenities such as Fireplace/Heating, Internet, and Laundry. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.