Vacation Rentals in Independence Square, Panama City: Compare 10+ Sites & Save

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1136 Best Vacation Rentals in Independence Square (Starting from $76)

Casa Lefevre by Wynwood House
Casa Lefevre by Wynwood House
Apartment
Panama City, Panama
0.0k from Independence Square center

Apartments, Accommodations, Lodgings, Places to stay, Self-catering

9 Bedrooms18 Guests
6.7

Good

31 reviews

$141
Average price / night
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w* | Homey Duplex in Plaza Catedral
w* | Homey Duplex in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Elevator, Internet, Kitchen, Laundry, Living Area, Microwave, No Smoking, TV

2 Bedrooms4 Guests
9.4

Superb

3 reviews

$203
Average price / night
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Lindo loft frente a la catedral en Casco Antiguo
Lindo loft frente a la catedral en Casco Antiguo
Apartment
Panama City, Panama
0.0k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Places to stay, Family, Self-catering

1 Bedroom4 Guests
9.0

Fabulous

2 reviews

$94
Average price / night
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w* | Majestic Duplex in Plaza Catedral
w* | Majestic Duplex in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Dryer, Elevator, Internet, Kitchen, Laundry, Living Area, Microwave, No Smoking

2 Bedrooms4 Guests
8.4

Very Good

6 reviews

$312
Average price / night
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YC l LOFT 1 BDR Casco Antiguo
YC l LOFT 1 BDR Casco Antiguo
Apartment
Panama City, Panama
0.0k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Places to stay, Self-catering

1 Bedroom4 Guests
10.0

Exceptional

1 reviews

$104
Average price / night
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w* | Peaceful 1BR in Plaza Catedral
w* | Peaceful 1BR in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Elevator, Internet, Kitchen, Laundry, Living Area, Microwave, No Smoking, TV

1 Bedroom2 Guests
7.6

Good

4 reviews

$172
Average price / night
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Casa Mallet by Wynwood House
Casa Mallet by Wynwood House
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Serviced apartments, Lodgings, Vacation rentals, Places to stay, Self-catering

12 Bedrooms24 Guests
9.2

Superb

68 reviews

$278
Average price / night
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w* | Whimsical 1BR in Plaza Catedral
w* | Whimsical 1BR in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Elevator, Internet, Kitchen, Laundry, Living Area, Microwave, No Smoking, TV

1 Bedroom2 Guests
6.0

Review score

2 reviews

$149
Average price / night
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Best Location - Spacious And Fancy Apt
Best Location - Spacious And Fancy Apt
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Vacation rentals, Places to stay, Family, Self-catering

1 Bedroom8 Guests
9.4

Superb

50 reviews

$153
Average price / night
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w* | Sunny Loft in Plaza Catedral
w* | Sunny Loft in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Elevator, Internet, Microwave, No Smoking, TV

1 Bedroom2 Guests
9.0

Fabulous

4 reviews

$110
Average price / night
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Best Location-fancy Apartment In Cascoviejo
Best Location-fancy Apartment In Cascoviejo
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Vacation rentals, Places to stay, Self-catering

1 Bedroom4 Guests
9.0

Fabulous

49 reviews

$103
Average price / night
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w* | Chic Loft in Plaza Catedral
w* | Chic Loft in Plaza Catedral
Apartment
Panamá, 843, Panama
0.0k from Independence Square center

AC, Elevator, Internet, Living Area, Microwave, No Smoking, TV

1 Bedroom4 Guests
New to Booking
$142
Average price / night
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AmazINN Places Casa Bandera I
AmazINN Places Casa Bandera I
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Vacation rentals, Places to stay

3 Bedrooms6 Guests
8.3

Very Good

3 reviews

$213
Average price / night
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AmazINN Places Casa Bandera III
AmazINN Places Casa Bandera III
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Lodgings, Vacation rentals, Places to stay

1 Bedroom2 Guests
8.5

Very Good

11 reviews

$168
Average price / night
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Boutique apartment in Old town
Boutique apartment in Old town
Apartment
Panamá, Panama
0.1k from Independence Square center

AC, Dryer, Internet, Laundry, No Smoking, Washer

1 Bedroom6 Guests
10.0

Exceptional

1 reviews

$121
Average price / night
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Amazinn Places Teatro Nacional
Amazinn Places Teatro Nacional
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Pet-friendly, Lodgings, Vacation rentals, Places to stay

1 Bedroom2 Guests
9.3

Superb

40 reviews

$174
Average price / night
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Charming Old Town Apartment with Stunning City Views
Charming Old Town Apartment with Stunning City Views
Apartment
Panamá, Panama
0.1k from Independence Square center

AC, Internet, No Smoking

1 Bedroom2 Guests
New to Booking
$120
Average price / night
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Apartamento en el corazón de Casco Viejo Panamá 14
Apartamento en el corazón de Casco Viejo Panamá 14
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Pet-friendly, Lodgings, Vacation rentals, Places to stay, Self-catering, Beach rentals

1 Bedroom2 Guests
9.5

Superb

2 reviews

$109
Average price / night
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Beautiful Boutique Apart-hotel view & services (La Isabela Suites)
Beautiful Boutique Apart-hotel view & services (La Isabela Suites)
Apartment
Panamá, Panama
0.1k from Independence Square center

AC, Balcony, Internet, Kitchen, Laundry, Microwave, No Smoking

1 Bedroom2 Guests
New to Booking
$204
Average price / night
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AmazINN Places Casa Bandera II
AmazINN Places Casa Bandera II
Apartment
Panama City, Panama
0.1k from Independence Square center

Apartments, Cheap, Accommodations, Pet-friendly, Lodgings, Vacation rentals, Places to stay

3 Bedrooms6 Guests
8.3

Very Good

7 reviews

$267
Average price / night
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Apartment
Apartment
Apartment
Panamá, 7092, Panama
0.1k from Independence Square center

AC, Balcony, Dryer, Elevator, Internet, Kitchen, Laundry, Living Area, Microwave

1 Bedroom2 Guests
8.8

Fabulous

6 reviews

$97
Average price / night
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Casa Acomodo Casco Viejo 4bdr Historic Mansion
Casa Acomodo Casco Viejo 4bdr Historic Mansion
House
Panama City, Panama
0.1k from Independence Square center

Accommodations, Villas, Vacation homes, Cottages, Pet-friendly, 4-star, Lodgings, Places to stay, Self-catering

11 Bedrooms25 Guests
7.7

Good

3 reviews

$76
Average price / night
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Apartamento en el Corazón de Casco Viejo Panamá 9
Apartamento en el Corazón de Casco Viejo Panamá 9
Apartment
Panamá, 7092, Panama
0.1k from Independence Square center

AC, Dryer, Fitness Equipment, Free Parking, Internet, Kitchen, Laundry, Living Area, Microwave

1 Bedroom4 Guests
New to Booking
$111
Average price / night
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w* | Bright 2BR w/ Balcony in Casco Viejo
w* | Bright 2BR w/ Balcony in Casco Viejo
Apartment
Panamá, 35400, Panama
0.1k from Independence Square center

AC, Balcony, Dryer, Elevator, Internet, Kitchen, Laundry, Microwave, No Smoking

2 Bedrooms4 Guests
9.8

Exceptional

6 reviews

$272
Average price / night
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w* | Sophisticated 1BR in Casco Viejo
w* | Sophisticated 1BR in Casco Viejo
Apartment
Panamá, 35400, Panama
0.1k from Independence Square center

AC, Balcony, Dryer, Elevator, Internet, Kitchen, Laundry, Microwave, No Smoking

1 Bedroom2 Guests
10.0

Exceptional

3 reviews

$184
Average price / night
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w* | Refined 2BR in Casco Viejo
w* | Refined 2BR in Casco Viejo
Apartment
Panamá, 35400, Panama
0.1k from Independence Square center

AC, Dryer, Elevator, Internet, Kitchen, Laundry, Microwave, No Smoking, TV

2 Bedrooms4 Guests
10.0

Exceptional

3 reviews

$273
Average price / night
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w* | Exclusive 2BR in Casco Viejo
w* | Exclusive 2BR in Casco Viejo
Apartment
Panamá, 35400, Panama
0.1k from Independence Square center

AC, Balcony, Dryer, Elevator, Internet, Kitchen, Laundry, Microwave, No Smoking

2 Bedrooms4 Guests
9.4

Superb

6 reviews

$288
Average price / night
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Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Independence Square.

Where to stay in Independence Square? Best neighborhoods & areas

Independence Square Vacation Rentals on the Map

Frequently Asked Questions

You can explore 1136 verified vacation rentals in Independence Square. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Independence Square vary depending on the season, property size, and location. Rates typically start from around $76 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Independence Square include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Independence Square welcome pets. Currently, 33 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it’s recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Independence Square often include amenities such as Accessibility, Balcony/Terrace, and Bedding/Linens. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.