Oceanfront Rentals in Mayo Clinic Florida, FL: Compare 10+ Sites & Save

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  5.  Jacksonville
  6.  Mayo Clinic Florida

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614 Best Oceanfront Rentals in Mayo Clinic Florida (Starting from $145)

Palm Escape
Palm Escape
House
Jacksonville, FL, USA
1.4k from Mayo Clinic Florida center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

2 Bedrooms10 Guests
New to Booking
$811
Average price / night
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Canal-Front Retreat 4 Mi to Jacksonville Beach!
Canal-Front Retreat 4 Mi to Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
0.9k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Free Parking, Heater, Kitchen, No Smoking, Outdoor Space, Patio

4 Bedrooms8 Guests
2.0

Review score

1 reviews

$305
Average price / night
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Condo near Jax Beach and Mayo Clinic
Condo near Jax Beach and Mayo Clinic
Apartment
FL, USA
2.2k from Mayo Clinic Florida center

Apartments, Cheap, Accommodations, Pools, Parking, Lodgings, Hot tubs, Places to stay, Family

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$153
Average price / night
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Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
9.8

Exceptional

38 reviews

$320
Average price / night
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Beach Retreat in Jacksonville PetandFamily-Friendly
Beach Retreat in Jacksonville PetandFamily-Friendly
House
Jacksonville Beach, FL, USA
3.7k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings, Vacation rentals

4 Bedrooms12 Guests
7.5

Good

4 reviews

$813
Average price / night
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SMV Palm Escape Retreat nr Mayo
SMV Palm Escape Retreat nr Mayo
House
Jacksonville, FL, 32250, United States
1.4k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
10.0

Exceptional

2 reviews

$648
Average price / night
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Beautiful Beach house with heated pool
Beautiful Beach house with heated pool
House
Jacksonville, FL, USA
3.9k from Mayo Clinic Florida center

Oceanfront, Air Conditioner, View, Guest Services, Pool, Security/Safety, Internet

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$246
Average price / night
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Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
House
Jacksonville, FL, 32250, United States
1.4k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms6 Guests
8.8

Fabulous

5 reviews

$353
Average price / night
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Pool & Hot Tub Home w Game Room! 1 Mile to Beach!
Pool & Hot Tub Home w Game Room! 1 Mile to Beach!
House
Jacksonville Beach, FL, USA
4.4k from Mayo Clinic Florida center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

4 Bedrooms16 Guests
9.2

Superb

7 reviews

$346
Average price / night
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Comfy Mayo Retreat; Heated Pool,  Close to Beach
Comfy Mayo Retreat; Heated Pool, Close to Beach
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.6

Exceptional

53 reviews

$449
Average price / night
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3 Bedroom Tropical Oasis in Jax Beach
3 Bedroom Tropical Oasis in Jax Beach
House
Jacksonville Beach, FL, USA
4.5k from Mayo Clinic Florida center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

3 Bedrooms6 Guests
9.7

Exceptional

3 reviews

$286
Average price / night
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Family-Friendly Jax Beach Retreat with Heated Pool
Family-Friendly Jax Beach Retreat with Heated Pool
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet

4 Bedrooms8 Guests
10.0

Exceptional

36 reviews

$495
Average price / night
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Walk to Jax Beach The Blue Oasis with Game Room
Walk to Jax Beach The Blue Oasis with Game Room
House
Jacksonville Beach, FL, USA
4.5k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

4 Bedrooms10 Guests
New to Booking
$634
Average price / night
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Beachy Bungalow: 3BR Home w/ Billiards/grill!
Beachy Bungalow: 3BR Home w/ Billiards/grill!
House
Jacksonville, FL, 32250, United States
2.0k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms8 Guests
10.0

Exceptional

2 reviews

$407
Average price / night
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Be A Nomad - Perfect for groups - Brand New
Be A Nomad - Perfect for groups - Brand New
Apartment
Jacksonville Beach, FL, USA
4.6k from Mayo Clinic Florida center

Apartments, Accommodations, Parking, Lodgings, Places to stay

4 Bedrooms10 Guests
New to Booking
$635
Average price / night
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Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
2.2k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
8.4

Very Good

19 reviews

$395
Average price / night
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SMV Minigolf and Splash Retreat
SMV Minigolf and Splash Retreat
House
Jacksonville Beach, FL, USA
4.7k from Mayo Clinic Florida center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

3 Bedrooms8 Guests
New to Booking
$522
Average price / night
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Windsor Wonders - Calm 2BR condo near Mayo
Windsor Wonders - Calm 2BR condo near Mayo
Condo
Jacksonville, FL, 32224, United States
2.2k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

2 Bedrooms4 Guests
6.0

Review score

1 reviews

$145
Average price / night
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Seventh Seas half mile to the beach pet friendly Near to the Mayo Clinic - UNF - TPC Sawgrass - Convention Center - Shopping Malls - Under 3 Hours from DISNEY
Seventh Seas half mile to the beach pet friendly Near to the Mayo Clinic - UNF - TPC Sawgrass - Convention Center - Shopping Malls - Under 3 Hours from DISNEY
House
Jacksonville Beach, FL, USA
4.7k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay, Family

3 Bedrooms8 Guests
4.5

Review score

2 reviews

$399
Average price / night
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Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
House
Jacksonville, FL, 32250, United States
2.4k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.8

Exceptional

109 reviews

$373
Average price / night
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Jax Vacations 1/2 Mile to Beach, 2 bedroom townhome pet friendly
Jax Vacations 1/2 Mile to Beach, 2 bedroom townhome pet friendly
House
Mayo Clinic Florida, Jacksonville, Florida, USA
4.7k from Mayo Clinic Florida center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals

2 Bedrooms6 Guests
9.2

Superb

5 reviews

$243
Average price / night
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Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
House
Jacksonville, FL, 32224, United States
2.4k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
9.8

Exceptional

6 reviews

$318
Average price / night
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Cozy 3 bedroom condo near Jax beach and Mayo Clinic
Cozy 3 bedroom condo near Jax beach and Mayo Clinic
Condo
Jacksonville, FL, 32224, United States
2.6k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Hot Tub, Internet

3 Bedrooms6 Guests
New to Booking
$161
Average price / night
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Peaceful Mayo Condo - 5 Min to Mayo, Pool & Gym, Beach & UNF Nearby
Peaceful Mayo Condo - 5 Min to Mayo, Pool & Gym, Beach & UNF Nearby
Condo
Jacksonville, FL, 32224, United States
2.6k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms5 Guests
10.0

Exceptional

6 reviews

$196
Average price / night
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Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
House
Jacksonville, FL, 32224, United States
2.9k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
8.0

Good

4 reviews

$291
Average price / night
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\"Sea Grape Villa\" Pool/ Ping Pong,
\"Sea Grape Villa\" Pool/ Ping Pong,
House
Jacksonville Beach, FL, 32250, United States
3.3k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Dryer, Heater, Hot Tub, Internet, Kitchen, Laundry

5 Bedrooms10 Guests
7.6

Good

8 reviews

$585
Average price / night
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10 minutes to the beach! Lake view house recently remodeled
10 minutes to the beach! Lake view house recently remodeled
House
Jacksonville, FL, 32224, United States
3.3k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms8 Guests
10.0

Exceptional

1 reviews

$350
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Oceanfront Rentals in Mayo Clinic Florida.

Where to stay in Mayo Clinic Florida? Best neighborhoods & areas

Mayo Clinic Florida Oceanfront Rentals on the Map

Frequently Asked Questions

You can explore 614 verified oceanfront rentals in Mayo Clinic Florida. These properties are located directly along the shoreline, offering uninterrupted access to the beach and ocean views.

Oceanfront rental prices in Mayo Clinic Florida vary depending on the property size, exact beachfront location, and season. Rates typically start from around $145 per night, with higher prices for larger homes or peak travel periods. Properties located directly on popular stretches of coastline tend to command premium rates.

Many oceanfront rentals in Mayo Clinic Florida offer direct access to the beach, often through private walkways or dedicated entry paths. Some properties may share access points, so it’s helpful to review the listing details to understand the type of beach access provided.

Yes, some oceanfront rentals in Mayo Clinic Florida welcome pets. Currently, 66 listings allow pets, although policies can vary by property. It’s recommended to check specific house rules for details such as size limits or additional fees.

Oceanfront properties are often in high demand, especially during peak travel seasons, so booking 90 to 120 days in advance is recommended for the best selection. During quieter periods, you may still find availability closer to your travel dates.

Oceanfront rentals in Mayo Clinic Florida often include features designed for a comfortable coastal stay, such as View, Ocean View, and Oceanfront. These amenities help guests make the most of their time by the water.

Yes, there is a clear difference. "Oceanfront" means the property is located directly on the beach with no obstructions between the home and the water. "Ocean View" typically means the ocean is visible from certain angles or rooms, but the property may not be right on the shoreline.