Hotels in Santo Spirito, Florence: Compare 10+ Sites & Save

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  3.  Italy
  4.  Tuscany

  5.  Florence
  6.  Santo Spirito

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725 Best Hotels in Santo Spirito (Starting from $48)

Hotel Firenze 2000
Hotel Firenze 2000
Hotel
Florence, Italy
0.4k from Santo Spirito center

Accommodations, Parking, Lodgings, Places to stay

6.8

Good

1570 reviews

$179
Average price / night
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Hotel Horto Convento
Hotel Horto Convento
Hotel
Viale Ariosto, 13, Florence, 50142, Italy
0.4k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Included, Elevator, Frontdesk 24 Hour, Heater, Housekeeping, Internet

9.8

Exceptional

633 reviews

$333
Average price / night
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Hotel Torre di Bellosguardo
Hotel Torre di Bellosguardo
Hotel
Santo Spirito, Florence, Italy
0.4k from Santo Spirito center

Accommodations, Pools, Parking, Pet-friendly, 4-star, Lodgings, Places to stay

8.8

Fabulous

204 reviews

$442
Average price / night
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Horto Convento
Horto Convento
Hotel
Florence, Italy
0.4k from Santo Spirito center

Luxury, Cheap, Accommodations, Parking, Romantic, Pet-friendly, 4-star, Lodgings, Places to stay

9.2

Superb

1483 reviews

$177
Average price / night
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Torre di Bellosguardo
Torre di Bellosguardo
Hotel
Via Roti Michelozzi 2, Florence, 50124, Italy
0.5k from Santo Spirito center

AC, Babysitting, Bar, Business Services, Crib, Elevator, Free Parking, Frontdesk 24 Hour, Housekeeping

9.0

Fabulous

103 reviews

$634
Average price / night
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UNA Hotels Vittoria Firenze
UNA Hotels Vittoria Firenze
Hotel
Florence, Italy
0.5k from Santo Spirito center

Cheap, Accommodations, Parking, Romantic, Boutique, Pet-friendly, 4-star, Lodgings, Places to stay

8.3

Very Good

1488 reviews

$187
Average price / night
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Casa Santo Nome di Gesu
Casa Santo Nome di Gesu
Hotel
Santo Spirito, Florence, Italy
0.7k from Santo Spirito center

Cheap, Accommodations, Parking, Lodgings, Places to stay

8.6

Fabulous

1936 reviews

$171
Average price / night
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Lungarno Vespucci 50
Lungarno Vespucci 50
Hotel
Lungarno Amerigo Vespucci 50, Florence, 50123, Italy
0.8k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Available, Business Services, Elevator, Frontdesk 24 Hour, Heater, Housekeeping

9.6

Exceptional

312 reviews

$228
Average price / night
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Hotel Relais Il Cestello
Hotel Relais Il Cestello
Hotel
Florence, Italy
0.7k from Santo Spirito center

Cheap, Accommodations, Romantic, 3-star, Lodgings, Places to stay

8.6

Fabulous

579 reviews

$48
Average price / night
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4F Boutique Hotel Florence
4F Boutique Hotel Florence
Hotel
Lungarno Amerigo Vespucci 58, Florence, 50123, Italy
0.9k from Santo Spirito center

AC, Bar, Elevator, Heater, Housekeeping, Internet, No Smoking, Parking Available, Room Service

9.6

Exceptional

82 reviews

$184
Average price / night
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Della Calza Retreat & Spa
Della Calza Retreat & Spa
Hotel
Florence, Italy
0.8k from Santo Spirito center

Business Services, Air Conditioner, Balcony/Terrace, Fireplace/Heating, Child Friendly, Transportation/Shuttle, Security/Safety

New to Booking
$228
Average price / night
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Hotel Principe
Hotel Principe
Hotel
Lungarno Vespucci Amerigo 34, Florence, 50123, Italy
0.9k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Included, Elevator, Frontdesk 24 Hour, Heater, Housekeeping, Internet

8.8

Fabulous

554 reviews

$199
Average price / night
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Ottantotto Firenze
Ottantotto Firenze
Hotel
Florence, Italy
0.8k from Santo Spirito center

Cheap, Accommodations, Lodgings, Places to stay

9.1

Superb

463 reviews

$260
Average price / night
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Gogò Petit Hotel
Gogò Petit Hotel
Hotel
Corso Italia, Florence, 50123, Italy
0.9k from Santo Spirito center

AC, Breakfast Available, Housekeeping, Internet, Parking Available, Soundproof Room, TV

9.2

Superb

109 reviews

$153
Average price / night
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Hotel Lungarno Vespucci 50
Hotel Lungarno Vespucci 50
Hotel
Florence, Italy
0.8k from Santo Spirito center

Luxury, Cheap, Accommodations, Parking, Romantic, Boutique, 4-star, Lodgings, Places to stay

9.0

Fabulous

426 reviews

$223
Average price / night
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Hotel Argentina
Hotel Argentina
Hotel
Via Curtatone, 12, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Crib, Elevator, Housekeeping, Internet, No Smoking, Room Service, TV

6.0

Review score

140 reviews

$140
Average price / night
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NH Firenze
NH Firenze
Hotel
Florence, Italy
0.9k from Santo Spirito center

Accommodations, Pools, Parking, Romantic, Boutique, Pet-friendly, 4-star, Lodgings, Places to stay

8.0

Good

1127 reviews

$196
Average price / night
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Hotel Palazzo Ognissanti
Hotel Palazzo Ognissanti
Hotel
Via Maso Finiguerra 12R, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Available, Elevator, Frontdesk 24 Hour, Housekeeping, Internet, Laundry

7.8

Good

491 reviews

$177
Average price / night
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Dedo Boutique Hotel
Dedo Boutique Hotel
Hotel
Florence, Italy
0.9k from Santo Spirito center

Cheap, Accommodations, Romantic, 3-star, Lodgings, Places to stay

8.7

Fabulous

1869 reviews

$359
Average price / night
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Anglo American Hotel Florence, Curio Collection by Hilton
Anglo American Hotel Florence, Curio Collection by Hilton
Hotel
Via Solferino, 6, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Available, Business Services, Crib, Elevator, Fitness Equipment, Free Parking

8.4

Very Good

813 reviews

$399
Average price / night
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Hotel Executive Florence
Hotel Executive Florence
Hotel
Via Curtatone 5, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Included, Business Services, Elevator, Fitness Equipment, Frontdesk 24 Hour, Heater

9.2

Superb

283 reviews

$215
Average price / night
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Arno Boutique
Arno Boutique
Hotel
Florence, Italy
0.9k from Santo Spirito center

Cheap, Accommodations, Parking, Lodgings, Places to stay

8.5

Very Good

573 reviews

$204
Average price / night
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The Excelsior, a Luxury Collection Hotel, Florence
The Excelsior, a Luxury Collection Hotel, Florence
Hotel
Piazza Ognissanti 3, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Available, Business Services, Crib, Elevator, Fitness Equipment, Frontdesk 24 Hour

9.4

Superb

363 reviews

$847
Average price / night
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BB Hotels Smarthotel Derose
BB Hotels Smarthotel Derose
Hotel
Florence, Italy
0.9k from Santo Spirito center

Luxury, Cheap, Accommodations, 4-star, Lodgings, Places to stay

9.0

Fabulous

1814 reviews

$115
Average price / night
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Hotel Magenta
Hotel Magenta
Hotel
Via Montebello 40, Florence, 50123, Italy
1.0k from Santo Spirito center

AC, Babysitting, Bar, Breakfast Included, Elevator, Frontdesk 24 Hour, Housekeeping, Internet, Laundry

8.4

Very Good

111 reviews

$208
Average price / night
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Hotel Annalena
Hotel Annalena
Hotel
Santo Spirito, Florence, Italy
0.9k from Santo Spirito center

Cheap, Accommodations, Romantic, Boutique, 3-star, Lodgings, Places to stay

8.5

Very Good

1515 reviews

$189
Average price / night
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Palazzo Guicciardini
Palazzo Guicciardini
Hotel
Santo Spirito, Florence, Italy
1.0k from Santo Spirito center

Cheap, Accommodations, Parking, Romantic, Pet-friendly, Lodgings, Places to stay, Family

8.8

Fabulous

804 reviews

$427
Average price / night
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Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Hotels in Santo Spirito.

Stay Near Santo Spirito's Top Attractions

VacationByOwnerRentals can help you find hotels, resorts, and rentals near many of 's top attractions, neighborhoods, and points of interest.

Santo Spirito Hotels on the Map

Frequently Asked Questions

You can explore 725 verified hotels in Santo Spirito. These include a range of options from luxury resorts and boutique hotels to budget-friendly accommodations suitable for different travel styles.

Hotel prices in Santo Spirito vary depending on the season, location, and property type. Rates typically start from around $48 per night, with higher prices for premium hotels, central locations, or peak travel dates.

Most hotels in Santo Spirito include amenities such as Guest Services, Accessibility, and Entertainment. Additional features like breakfast, parking, or resort facilities may vary by property, so it’s helpful to review the details before booking.

You can identify top-rated hotels in Santo Spirito by sorting listings based on guest ratings and reviews. Looking at recent feedback, overall scores, and review volume can help you find properties that consistently deliver a high-quality experience.

For popular travel periods or busy locations, booking 30 to 60 days in advance is generally recommended to secure preferred options. During quieter periods, you may find more flexibility and availability closer to your travel dates.

Yes, some hotels in Santo Spirito welcome pets. Currently, 27 listings allow pets, although policies may vary. It’s a good idea to review any pet-related rules before booking.

Many hotels in Santo Spirito offer flexible or refundable booking options. Checking the cancellation policy before confirming your reservation can help you choose a rate that suits your travel plans.