Hotels in Medi Center, CA: Compare 10+ Sites & Save

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547 Best Hotels in Medi Center (Starting from $69)

Good Life Resorts
Good Life Resorts
Hotel
San Diego, CA, USA
1.7k from Medi Center center

Cheap, Accommodations, Parking, Lodgings, Places to stay, Family, Self-catering

8.8

Fabulous

14 reviews

$554
Average price / night
Check Availability
Good Life Vacation Rental Resort
Good Life Vacation Rental Resort
Hotel
3209 Market St, San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Bar, Barbecue, Business Services, Free Parking, Heater, Internet, Laundry, No Smoking

9.4

Superb

34 reviews

$597
Average price / night
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Lodge at 32nd
Lodge at 32nd
Hotel
San Diego, CA, USA
1.8k from Medi Center center

Accommodations, Motels, Parking, Lodgings, Places to stay, Accessible hotels

7.2

Good

160 reviews

$69
Average price / night
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Spacious Private Retreat with Event Spaces
Spacious Private Retreat with Event Spaces
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

New to Booking
$2180
Average price / night
Check Availability
Quality Inn San Diego I-5 Naval Base
Quality Inn San Diego I-5 Naval Base
Hotel
San Diego, CA, USA
3.2k from Medi Center center

B&bs, Accommodations, Parking, Inns, Lodgings, Places to stay, Accessible hotels

7.4

Good

347 reviews

$104
Average price / night
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Family Retreat with 11BR 26 Beds
Family Retreat with 11BR 26 Beds
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Heater, Internet, Kitchen

New to Booking
$2149
Average price / night
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Hotel Narcissus
Hotel Narcissus
Hotel
San Diego, CA, USA
3.6k from Medi Center center

Security/Safety, Internet

New to Booking
$152
Average price / night
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Resort Perks: 17-bed Surf lof.t private deck
Resort Perks: 17-bed Surf lof.t private deck
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Dryer, Extra Bed, Fitness Equipment, Free Parking, Heater, Internet

9.6

Exceptional

5 reviews

$1183
Average price / night
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Studio 6-National City, CA - Naval Base San Diego
Studio 6-National City, CA - Naval Base San Diego
Hotel
National City, CA, USA
3.7k from Medi Center center

Accommodations, Parking, Pet-friendly, 3-star, Lodgings, Places to stay

7.4

Good

299 reviews

$89
Average price / night
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3 Resort Suites with kitchen + Event Space Access
3 Resort Suites with kitchen + Event Space Access
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

10.0

Exceptional

1 reviews

$1075
Average price / night
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Rodeway Inn National City San Diego South
Rodeway Inn National City San Diego South
Hotel
National City, CA, USA
3.8k from Medi Center center

B&bs, Accommodations, Parking, Inns, Lodgings, Places to stay, Accessible hotels

7.0

Good

220 reviews

$130
Average price / night
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Resort Perks: 8 beds, Sun Cott.age, deck & kitchen
Resort Perks: 8 beds, Sun Cott.age, deck & kitchen
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Dryer, Fitness Equipment, Heater, Internet, Kitchen, Laundry

New to Booking
$503
Average price / night
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Howard Johnson by Wyndham National City/San Diego South
Howard Johnson by Wyndham National City/San Diego South
Hotel
National City, CA, USA
3.8k from Medi Center center

Accommodations, Lodgings, Places to stay, Accessible hotels

7.2

Good

665 reviews

$155
Average price / night
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Private Resort, Multiple Houses. 48 guests. Expandable.
Private Resort, Multiple Houses. 48 guests. Expandable.
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

9.0

Fabulous

2 reviews

$2976
Average price / night
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Ramada by Wyndham San Diego National City
Ramada by Wyndham San Diego National City
Hotel
National City, CA, USA
3.9k from Medi Center center

Bar, Hot Tub, Internet, Smoking, Guest Services, Restaurant, Balcony/Terrace

6.8

Good

42 reviews

$169
Average price / night
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PRIVATE RESORT – SLEEPS 48 - Event Spaces Included
PRIVATE RESORT – SLEEPS 48 - Event Spaces Included
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

8.0

Good

1 reviews

$3433
Average price / night
Check Availability
Holiday Inn Express San Diego South - National City by IHG
Holiday Inn Express San Diego South - National City by IHG
Hotel
National City, CA, USA
4.2k from Medi Center center

Accommodations, Pools, Parking, Holiday inn , Lodgings, Places to stay, Accessible hotels

8.8

Fabulous

251 reviews

$200
Average price / night
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Resort: 34 BRs, 95 Beds & 5 Stunning Event Spaces
Resort: 34 BRs, 95 Beds & 5 Stunning Event Spaces
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Arcade, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

New to Booking
$10481
Average price / night
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Sentral Gaslamp Quarter
Sentral Gaslamp Quarter
Hotel
San Diego, CA, USA
4.6k from Medi Center center

Cheap, Accommodations, Parking, Pet-friendly, 4-star, Lodgings, Places to stay, Self-catering, Accessible hotels

8.6

Fabulous

243 reviews

$228
Average price / night
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Resort Perks: 10 beds, Beach Hou.se, deck & kitchen
Resort Perks: 10 beds, Beach Hou.se, deck & kitchen
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

10.0

Exceptional

1 reviews

$786
Average price / night
Check Availability
The Davis Downtown San Diego
The Davis Downtown San Diego
Hotel
San Diego, CA, USA
4.6k from Medi Center center

Accommodations, Pet-friendly, 3-star, Lodgings, Places to stay

7.8

Good

166 reviews

$227
Average price / night
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Hawaiian Lof.t w/ Vinyl Player. Speakeasy included
Hawaiian Lof.t w/ Vinyl Player. Speakeasy included
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

10.0

Exceptional

2 reviews

$1410
Average price / night
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Hotel Indigo San Diego - Gaslamp Quarter by IHG
Hotel Indigo San Diego - Gaslamp Quarter by IHG
Hotel
San Diego, CA, USA
4.7k from Medi Center center

Accommodations, Parking, Romantic, Boutique, Pet-friendly, 4-star, Lodgings, Places to stay, Family

8.7

Fabulous

687 reviews

$331
Average price / night
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Resort Perks: 11 beds, monastery bunks, kitchen
Resort Perks: 11 beds, monastery bunks, kitchen
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

10.0

Exceptional

1 reviews

$431
Average price / night
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Downtown San Diego Lodge
Downtown San Diego Lodge
Hotel
San Diego, CA, USA
4.7k from Medi Center center

Security/Safety, Pet Friendly, Guest Services, Air Conditioner, Internet, Fireplace/Heating, Parking

5.3

Review score

312 reviews

$171
Average price / night
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Resort Perks: Lookout Suite + kitchen + game tent
Resort Perks: Lookout Suite + kitchen + game tent
Hotel
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Crib, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave

New to Booking
$396
Average price / night
Check Availability
Hotel Gigi
Hotel Gigi
Hotel
San Diego, CA, USA
4.7k from Medi Center center

Accommodations, 3-star, Lodgings, Places to stay

7.7

Good

201 reviews

$275
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Hotels in Medi Center.

Where to stay in Medi Center? Best neighborhoods & areas

Medi Center Hotels on the Map

Frequently Asked Questions

You can explore 547 verified hotels in Medi Center. These include a range of options from luxury resorts and boutique hotels to budget-friendly accommodations suitable for different travel styles.

Hotel prices in Medi Center vary depending on the season, location, and property type. Rates typically start from around $69 per night, with higher prices for premium hotels, central locations, or peak travel dates.

Most hotels in Medi Center include amenities such as Laundry, Kitchen, and Internet. Additional features like breakfast, parking, or resort facilities may vary by property, so it’s helpful to review the details before booking.

You can identify top-rated hotels in Medi Center by sorting listings based on guest ratings and reviews. Looking at recent feedback, overall scores, and review volume can help you find properties that consistently deliver a high-quality experience.

For popular travel periods or busy locations, booking 30 to 60 days in advance is generally recommended to secure preferred options. During quieter periods, you may find more flexibility and availability closer to your travel dates.

Yes, some hotels in Medi Center welcome pets. Currently, 25 listings allow pets, although policies may vary. It’s a good idea to review any pet-related rules before booking.

Many hotels in Medi Center offer flexible or refundable booking options. Checking the cancellation policy before confirming your reservation can help you choose a rate that suits your travel plans.