Hotels in Clayton, MO: Compare 10+ Sites & Save

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126 Best Hotels in Clayton (Starting from $123)

Homewood Suites by Hilton St. Louis - Galleria
Homewood Suites by Hilton St. Louis - Galleria
Hotel
Richmond Heights, MO, USA
2.2k from Clayton center

Accommodations, Pools, Parking, Hilton , Pet-friendly, 3-star, Lodgings, Hot tubs, Places to stay

8.0

Good

69 reviews

$192
Average price / night
Check Availability
MainStay Suites St Louis - Galleria
MainStay Suites St Louis - Galleria
Hotel
Richmond Heights, MO, USA
2.3k from Clayton center

Accommodations, Pools, Parking, Pet-friendly, 3-star, Lodgings, Places to stay, Family, Accessible hotels

6.2

Good

7 reviews

$148
Average price / night
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Drury Inn & Suites St. Louis Brentwood
Drury Inn & Suites St. Louis Brentwood
Hotel
Brentwood, MO, USA
2.4k from Clayton center

Cheap, Accommodations, Pools, Parking, 3-star, Lodgings, Jacuzzis, Places to stay, Accessible hotels

9.2

Superb

483 reviews

$258
Average price / night
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Drury Plaza Hotel St. Louis Brentwood
Drury Plaza Hotel St. Louis Brentwood
Hotel
8700 Eager Rd, Brentwood, MO, 63144, United States
2.5k from Clayton center

AC, Bar, Breakfast Included, Business Services, Crib, Elevator, Extra Bed, Fitness Equipment, Free Parking

9.6

Exceptional

1003 reviews

$181
Average price / night
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Residence Inn by Marriott St Louis Clayton
Residence Inn by Marriott St Louis Clayton
Hotel
Clayton, MO, USA
2.6k from Clayton center

Cheap, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay, Family, Accessible hotels

9.0

Fabulous

66 reviews

$219
Average price / night
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AC Hotel by Marriott St. Louis Clayton
AC Hotel by Marriott St. Louis Clayton
Hotel
Clayton, MO, USA
2.7k from Clayton center

Accommodations, Parking, 3-star, Lodgings, Places to stay, Accessible hotels

8.4

Very Good

43 reviews

$216
Average price / night
Check Availability
AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton
Hotel
227 South Central Ave, St. Louis, MO, 63105, United States
2.7k from Clayton center

AC, Bar, Breakfast Available, Business Services, Crib, Elevator, Fitness Equipment, Frontdesk 24 Hour, Grocery

9.0

Fabulous

274 reviews

$168
Average price / night
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Seven Gables Inn, St Louis West, a Tribute Portfolio Hotel
Seven Gables Inn, St Louis West, a Tribute Portfolio Hotel
Hotel
Saint Louis, MO, USA
2.9k from Clayton center

Cheap, Accommodations, Parking, 4-star, Lodgings, Places to stay

7.7

Good

19 reviews

$193
Average price / night
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Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
Hotel
7730 Bonhomme Ave, St. Louis, MO, 63105, United States
2.9k from Clayton center

AC, Bar, Breakfast Available, Business Services, Crib, Elevator, Fitness Equipment, Frontdesk 24 Hour, Housekeeping

8.8

Fabulous

707 reviews

$168
Average price / night
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Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
Hotel
Clayton, MO, USA
3.0k from Clayton center

Cheap, Accommodations, Pools, Parking, Romantic, Pet-friendly, 4-star, Lodgings, Places to stay

8.3

Very Good

1258 reviews

$123
Average price / night
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Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Hotel
26 North Meramec Avenue, St. Louis, MO, 63105, United States
2.9k from Clayton center

AC, Bar, Business Services, Elevator, Frontdesk 24 Hour, Housekeeping, Internet, No Smoking, Outdoor Space

8.4

Very Good

587 reviews

$172
Average price / night
Check Availability
Hampton Inn and Suites Clayton/St. Louis-Galleria Area
Hampton Inn and Suites Clayton/St. Louis-Galleria Area
Hotel
Clayton, MO, USA
3.1k from Clayton center

Accommodations, Pools, Parking, Pet-friendly, 3-star, Lodgings, Places to stay, Family, Accessible hotels

8.3

Very Good

105 reviews

$178
Average price / night
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Modern Room Close to Saint Louis Art Museum - 20 Minutes Away from Downtown
Modern Room Close to Saint Louis Art Museum - 20 Minutes Away from Downtown
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$266
Average price / night
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Hilton St. Louis Frontenac
Hilton St. Louis Frontenac
Hotel
Clayton, St. Louis, Missouri, USA
3.3k from Clayton center

Accommodations, Pools, Parking, Hilton , 3-star, Lodgings, Places to stay, Family, Accessible hotels

8.2

Very Good

204 reviews

$178
Average price / night
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Clean and Comfortable Room Near St. Louis Art Museum and St. Louis Zoo - 4 miles
Clean and Comfortable Room Near St. Louis Art Museum and St. Louis Zoo - 4 miles
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$267
Average price / night
Check Availability
Courtyard St. Louis Brentwood
Courtyard St. Louis Brentwood
Hotel
Richmond Heights, MO, USA
3.3k from Clayton center

Cheap, Accommodations, Parking, Marriott , 3-star, Lodgings, Places to stay, Family, Accessible hotels

8.7

Fabulous

106 reviews

$161
Average price / night
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Pet-Friendly and Modern Room for Families Near St. Louis Zoo and Cultural Sites
Pet-Friendly and Modern Room for Families Near St. Louis Zoo and Cultural Sites
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$270
Average price / night
Check Availability
TownePlace Suites by Marriott Brentwood
TownePlace Suites by Marriott Brentwood
Hotel
Brentwood, MO, USA
3.3k from Clayton center

Cheap, Accommodations, Pools, Marriott , Pet-friendly, 3-star, Lodgings, Places to stay, Family

8.6

Fabulous

215 reviews

$152
Average price / night
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Modern Room Perfect Groups Exploring Clayton & Beyond - 20 Minutes from Downtown
Modern Room Perfect Groups Exploring Clayton & Beyond - 20 Minutes from Downtown
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$270
Average price / night
Check Availability
SpringHill Suites St. Louis Brentwood
SpringHill Suites St. Louis Brentwood
Hotel
Brentwood, MO, USA
3.4k from Clayton center

Cheap, Accommodations, Parking, Pet-friendly, 3-star, Lodgings, Places to stay, Family

8.4

Very Good

109 reviews

$149
Average price / night
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Comfortable Room a Short Drive from Missouri Botanical Gardens and Forest Park
Comfortable Room a Short Drive from Missouri Botanical Gardens and Forest Park
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$294
Average price / night
Check Availability
The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis
Hotel
Clayton, MO, USA
3.5k from Clayton center

Luxury, Accommodations, Parking, Spa, Pet-friendly, 5-star, Lodgings, Places to stay, Family

8.1

Very Good

29 reviews

$619
Average price / night
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Modern Room Near Clayton’s Charming Bars & Eateries - Explore St. Louis Zoo
Modern Room Near Clayton’s Charming Bars & Eateries - Explore St. Louis Zoo
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$294
Average price / night
Check Availability
The Knight Center at Washington University
The Knight Center at Washington University
Hotel
University City, MO, USA
5.1k from Clayton center

Cheap, Accommodations, Parking, Lodgings, Places to stay

8.7

Fabulous

15 reviews

$174
Average price / night
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2 Comfortable Rooms near St. Louis Gateway Arch and Missouri History Museum
2 Comfortable Rooms near St. Louis Gateway Arch and Missouri History Museum
Hotel
Clayton, MO, 63105, United States
3.1k from Clayton center

AC, Breakfast Included, Elevator, Fitness Equipment, Free Parking, Heater, Internet, Microwave, No Smoking

New to Booking
$589
Average price / night
Check Availability
The Cheshire
The Cheshire
Hotel
Saint Louis, MO, USA
5.5k from Clayton center

B&bs, Accommodations, Pools, Parking, Inns, Boutique, Pet-friendly, 4-star, Lodgings

7.7

Good

191 reviews

$197
Average price / night
Check Availability
The Moonrise Hotel
The Moonrise Hotel
Hotel
Saint Louis, MO, USA
6.4k from Clayton center

Cheap, Accommodations, Parking, Romantic, Boutique, Pet-friendly, 4-star, Lodgings, Places to stay

8.3

Very Good

767 reviews

$251
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Hotels in Clayton.

Stay Near Clayton's Top Attractions

VacationByOwnerRentals can help you find hotels, resorts, and rentals near many of 's top attractions, neighborhoods, and points of interest.

Clayton Hotels on the Map

Frequently Asked Questions

You can explore 126 verified hotels in Clayton. These include a range of options from luxury resorts and boutique hotels to budget-friendly accommodations suitable for different travel styles.

Hotel prices in Clayton vary depending on the season, location, and property type. Rates typically start from around $123 per night, with higher prices for premium hotels, central locations, or peak travel dates.

Most hotels in Clayton include amenities such as Accessibility, Wheelchair Accessible, and Guest Services. Additional features like breakfast, parking, or resort facilities may vary by property, so it’s helpful to review the details before booking.

You can identify top-rated hotels in Clayton by sorting listings based on guest ratings and reviews. Looking at recent feedback, overall scores, and review volume can help you find properties that consistently deliver a high-quality experience.

For popular travel periods or busy locations, booking 30 to 60 days in advance is generally recommended to secure preferred options. During quieter periods, you may find more flexibility and availability closer to your travel dates.

Yes, some hotels in Clayton welcome pets. Currently, 32 listings allow pets, although policies may vary. It’s a good idea to review any pet-related rules before booking.

Many hotels in Clayton offer flexible or refundable booking options. Checking the cancellation policy before confirming your reservation can help you choose a rate that suits your travel plans.