Family-Friendly Vacation Rentals in Medi Center, CA: Compare 10+ Sites & Save

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848 Best Family Vacation Rentals in Medi Center (Starting from $84)

San Diego's Cozy Gem
San Diego's Cozy Gem
House
San Diego, CA, USA
0.3k from Medi Center center

Cheap, Accommodations, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay, Family

1 Bedroom2 Guests
9.9

Exceptional

8 reviews

$117
Average price / night
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Modern 2 Bedroom w/ Huge Yard - 5 min to Downtown!
Modern 2 Bedroom w/ Huge Yard - 5 min to Downtown!
House
San Diego, CA, 92102, United States
0.3k from Medi Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

2 Bedrooms6 Guests
4.0

Review score

1 reviews

$252
Average price / night
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San Diego Gem with Private Hot Tub, Close to Dtwn!
San Diego Gem with Private Hot Tub, Close to Dtwn!
House
San Diego, CA, USA
1.3k from Medi Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals, Hot tubs

3 Bedrooms8 Guests
8.0

Good

1 reviews

$292
Average price / night
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Luxury 5 Bedrooms with FREE Heated Pool & SPA, Arcades, and Central Location
Luxury 5 Bedrooms with FREE Heated Pool & SPA, Arcades, and Central Location
Villa
San Diego, CA, 92102, United States
0.3k from Medi Center center

Arcade, Balcony, Barbecue, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet

5 Bedrooms16 Guests
8.4

Very Good

6 reviews

$1097
Average price / night
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Condé Nast's top-rated Vacation home for 2 years running!
Condé Nast's top-rated Vacation home for 2 years running!
House
San Diego, CA, USA
1.5k from Medi Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Jacuzzis, Places to stay

3 Bedrooms10 Guests
New to Booking
$667
Average price / night
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HEART OF SD! Luxury Villa w Hot Tub, Fireplace and Oversized Fully Lit Backyard
HEART OF SD! Luxury Villa w Hot Tub, Fireplace and Oversized Fully Lit Backyard
House
San Diego, CA, 92113, United States
0.9k from Medi Center center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet, Kitchen

3 Bedrooms6 Guests
9.6

Exceptional

18 reviews

$334
Average price / night
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Trendy San Diego Home with Outdoor Space
Trendy San Diego Home with Outdoor Space
House
San Diego, CA, USA
1.5k from Medi Center center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals

1 Bedroom4 Guests
8.9

Fabulous

8 reviews

$360
Average price / night
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Charming 3-bedroom house in lovely San Diego with AC, WiFi
Charming 3-bedroom house in lovely San Diego with AC, WiFi
House
San Diego, CA, 92113, United States
1.5k from Medi Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave, No Smoking

3 Bedrooms7 Guests
New to Booking
$426
Average price / night
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San Diego Sanctuary with Hot Tub and Large Patio!
San Diego Sanctuary with Hot Tub and Large Patio!
House
San Diego, CA, USA
1.6k from Medi Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Hot tubs, Places to stay

4 Bedrooms8 Guests
8.0

Good

3 reviews

$352
Average price / night
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Private Home great single story home. Plenty of space for the family.
Private Home great single story home. Plenty of space for the family.
House
San Diego, CA, 92105, United States
1.6k from Medi Center center

AC, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms6 Guests
10.0

Exceptional

100 reviews

$323
Average price / night
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4 Mi to Dtwn San Diego Cozy Getaway with Patio!
4 Mi to Dtwn San Diego Cozy Getaway with Patio!
House
San Diego, CA, USA
1.7k from Medi Center center

Accessibility, Pet Friendly, Security/Safety, Fireplace/Heating, Internet, Guest Services, Parking

3 Bedrooms6 Guests
New to Booking
$265
Average price / night
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Modern 4BR; Convention Ctr~2mi; Yard/Patio/Outdoor Bar; AC, W/D, 4-car Parking!
Modern 4BR; Convention Ctr~2mi; Yard/Patio/Outdoor Bar; AC, W/D, 4-car Parking!
House
San Diego, CA, 92102, United States
1.6k from Medi Center center

AC, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Laundry, Living Area

4 Bedrooms12 Guests
10.0

Exceptional

1 reviews

$501
Average price / night
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Luxury NEW Residence with Private Rooftop, Downtown in minutes
Luxury NEW Residence with Private Rooftop, Downtown in minutes
Apartment
San Diego, CA, USA
1.8k from Medi Center center

Apartments, Luxury, Cheap, Accommodations, Parking, Lodgings, Places to stay, Family, Self-catering

3 Bedrooms7 Guests
9.3

Superb

3 reviews

$546
Average price / night
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5 Min to Balboa Park Zoo & 10 to Gaslamp/Downtown
5 Min to Balboa Park Zoo & 10 to Gaslamp/Downtown
House
San Diego, CA, 92102, United States
1.7k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Heater, Internet, Kitchen, Microwave

2 Bedrooms6 Guests
10.0

Exceptional

1 reviews

$433
Average price / night
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3BRB with Bonus Bedroom, Hot Tub, Tropical Oasis
3BRB with Bonus Bedroom, Hot Tub, Tropical Oasis
House
San Diego, CA, USA
1.8k from Medi Center center

Wellness Facilities, Sports/Activities, Child Friendly, Balcony/Terrace, Barbecue/Outdoor Cooking, Security/Safety, Oceanfront

4 Bedrooms11 Guests
New to Booking
$560
Average price / night
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One bedroom apt/guest home near downtown and base\n
One bedroom apt/guest home near downtown and base\n
House
San Diego, CA, 92113, United States
1.8k from Medi Center center

AC, Hot Tub, Internet, Kitchen, Living Area, No Smoking, Outdoor Space, TV

1 Bedroom3 Guests
New to Booking
$84
Average price / night
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San Diego Oasis with Hot Tub, Gym, Outdoor Theater, Huge Yard
San Diego Oasis with Hot Tub, Gym, Outdoor Theater, Huge Yard
House
San Diego, CA, USA
1.9k from Medi Center center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

4 Bedrooms10 Guests
10.0

Exceptional

2 reviews

$1081
Average price / night
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San Diego's 4-bed Oasis with Hot Tub,  Gym, Outdoor Theater & Huge Yard.
San Diego's 4-bed Oasis with Hot Tub, Gym, Outdoor Theater & Huge Yard.
Villa
San Diego, CA, 92104, United States
1.8k from Medi Center center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Hot Tub

4 Bedrooms10 Guests
New to Booking
$811
Average price / night
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Sip, Shop and Explore San Diego Apartment
Sip, Shop and Explore San Diego Apartment
Apartment
San Diego, CA, USA
2.0k from Medi Center center

Apartments, Accommodations, Parking, Lodgings, Places to stay

1 Bedroom4 Guests
New to Booking
$218
Average price / night
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San Diego Modern Luxxe Retreat-Pool, Hot Tub & Speakeasy
San Diego Modern Luxxe Retreat-Pool, Hot Tub & Speakeasy
House
San Diego, CA, 92105, United States
1.8k from Medi Center center

AC, Arcade, Barbecue, Crib, Dryer, Free Parking, Heater, Hot Tub, Internet

4 Bedrooms11 Guests
New to Booking
$1288
Average price / night
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1 Mi to Balboa Park Apt with Furnished Patio!
1 Mi to Balboa Park Apt with Furnished Patio!
Apartment
San Diego, CA, USA
2.0k from Medi Center center

Apartments, Accommodations, Parking, Lodgings, Places to stay

1 Bedroom5 Guests
New to Booking
$211
Average price / night
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Charming 4-Bedroom Retreat, Just 5 Minutes from San Diego’s Beautiful Beach
Charming 4-Bedroom Retreat, Just 5 Minutes from San Diego’s Beautiful Beach
House
San Diego, CA, 92102, United States
1.9k from Medi Center center

AC, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
8.8

Fabulous

6 reviews

$619
Average price / night
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 Pet Friendly SouthPark Bungalow
Pet Friendly SouthPark Bungalow
House
San Diego, CA, 92102, United States
1.9k from Medi Center center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

2 Bedrooms5 Guests
9.8

Exceptional

38 reviews

$281
Average price / night
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5 minutes to San Diego Zoo w/pool - The San Diego Poolside Paradise
5 minutes to San Diego Zoo w/pool - The San Diego Poolside Paradise
House
San Diego, CA, 92104, United States
1.9k from Medi Center center

AC, Arcade, Barbecue, Dryer, Extra Bed, Free Parking, Heater, Internet, Kitchen

3 Bedrooms9 Guests
10.0

Exceptional

22 reviews

$728
Average price / night
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Sip, Shop & Explore: San Diego Apartment
Sip, Shop & Explore: San Diego Apartment
Apartment
San Diego, CA, 92102, United States
2.0k from Medi Center center

AC, Barbecue, Dryer, Free Parking, Heater, Kitchen, Laundry, Microwave, No Smoking

1 Bedroom3 Guests
8.0

Good

1 reviews

$244
Average price / night
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Golden Hill 3BR • Sleeps 8 • Near Zoo & Downtown
Golden Hill 3BR • Sleeps 8 • Near Zoo & Downtown
House
San Diego, CA, 92102, United States
2.0k from Medi Center center

AC, Barbecue, Crib, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms8 Guests
9.0

Fabulous

2 reviews

$546
Average price / night
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Updated San Diego Home w/ Private Yard & Patio!
Updated San Diego Home w/ Private Yard & Patio!
House
San Diego, CA, 92102-1327, United States
2.0k from Medi Center center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave

3 Bedrooms6 Guests
8.6

Fabulous

18 reviews

$410
Average price / night
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Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Family Vacation Rentals in Medi Center.

Where to stay in Medi Center? Best neighborhoods & areas

Medi Center Family Vacation Rentals on the Map

Frequently Asked Questions

You can explore 848 verified family-friendly vacation rentals in Medi Center. These include spacious homes, villas, and condos designed to accommodate families of different sizes.

Prices for family-friendly rentals in Medi Center vary depending on the season, number of bedrooms, and included amenities. Rates typically start from around $84 per night, with larger homes and peak travel periods often costing more.

Many family-friendly rentals in Medi Center offer baby-friendly items such as high chairs, cribs, or pack-and-play options. Availability can vary, so it’s helpful to check the listing details before booking.

Yes, some rentals in Medi Center are well suited for multi-generational stays, offering multiple bedrooms, separate living areas, and enough space for larger groups to stay comfortably together.

For busy travel periods such as school holidays or summer breaks, booking 90 to 120 days in advance is recommended to secure the best options. Availability may be more flexible during quieter times of the year.

Family-friendly rentals in Medi Center often include amenities such as Child Friendly, Fireplace/Heating, and Internet. These features help make stays more convenient and enjoyable for both adults and children.

You can use search filters to find rentals that offer features like game rooms, playgrounds, or entertainment areas. Checking property descriptions can also help you identify homes that are well suited for families with children.