Family-Friendly Vacation Rentals in Mayo Clinic Scottsdale, AZ: Compare 10+ Sites & Save

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416 Best Family Vacation Rentals in Mayo Clinic Scottsdale (Starting from $121)

Elegant Scottsdale Desert Retreat with Private Pool, Hot Tub, Game Room, and Family-Friendly Amenities
Elegant Scottsdale Desert Retreat with Private Pool, Hot Tub, Game Room, and Family-Friendly Amenities
House
Scottsdale, AZ, USA
0.7k from Mayo Clinic Scottsdale center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

5 Bedrooms13 Guests
10.0

Exceptional

1 reviews

$666
Average price / night
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Prime Location, Heated Saltwater Pool, Access to Tennis Courts, BBQ, and More!
Prime Location, Heated Saltwater Pool, Access to Tennis Courts, BBQ, and More!
House
Scottsdale, AZ, 85259, United States
1.0k from Mayo Clinic Scottsdale center

AC, Barbecue, Breakfast Available, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet

3 Bedrooms6 Guests
New to Booking
$229
Average price / night
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Luxury Mountain Estate-Pool-Spa-BBQ+Bar-Fire pit
Luxury Mountain Estate-Pool-Spa-BBQ+Bar-Fire pit
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Luxury, Accommodations, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

6 Bedrooms14 Guests
New to Booking
$2739
Average price / night
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Luxury 5200sf/1 acre Desert Villa w pool/spa/mountain views
Luxury 5200sf/1 acre Desert Villa w pool/spa/mountain views
Villa
Scottsdale, AZ, 85259, United States
1.0k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater

5 Bedrooms16 Guests
10.0

Exceptional

37 reviews

$1208
Average price / night
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NEW Gold Dust Private Villa
NEW Gold Dust Private Villa
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$911
Average price / night
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Private Scottsdale Estate | Pool , Spa & Views
Private Scottsdale Estate | Pool , Spa & Views
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater

5 Bedrooms10 Guests
9.6

Exceptional

4 reviews

$881
Average price / night
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Luxe Scottsdale Home with Pool and Mountain Views!
Luxe Scottsdale Home with Pool and Mountain Views!
House
Scottsdale, AZ, USA
1.1k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings

6 Bedrooms15 Guests
10.0

Exceptional

1 reviews

$977
Average price / night
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Magnificent Mountainside Estate with Ultimate Privacy
Magnificent Mountainside Estate with Ultimate Privacy
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Balcony, Barbecue, Business Services, Crib, Dryer, Fireplace, Fitness Equipment

8 Bedrooms18 Guests
9.6

Exceptional

17 reviews

$2377
Average price / night
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Midnight At The Oasis
Midnight At The Oasis
House
Scottsdale, AZ, USA
1.2k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Spa, Cottages, Lodgings, Places to stay

7 Bedrooms16 Guests
New to Booking
$1637
Average price / night
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Arcadia by AvantStay Breathtaking Oasis in Scottsdale w Pool Hot Tub Game Room
Arcadia by AvantStay Breathtaking Oasis in Scottsdale w Pool Hot Tub Game Room
Villa
Scottsdale, AZ, USA
1.3k from Mayo Clinic Scottsdale center

Cheap, Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings

4 Bedrooms10 Guests
10.0

Exceptional

1 reviews

$483
Average price / night
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Luxe Scottsdale Home w/ Pool & Mountain Views!
Luxe Scottsdale Home w/ Pool & Mountain Views!
House
Scottsdale, AZ, 85259-3531, United States
1.1k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Kitchen

6 Bedrooms15 Guests
9.6

Exceptional

27 reviews

$608
Average price / night
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The Scottsdale Haven w Heated Pool, 7 bed & 7 bath
The Scottsdale Haven w Heated Pool, 7 bed & 7 bath
House
Scottsdale, AZ, USA
2.0k from Mayo Clinic Scottsdale center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom14 Guests
New to Booking
$2025
Average price / night
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Scottsdale Sunset Retreat | Patio, Spa  & Views
Scottsdale Sunset Retreat | Patio, Spa & Views
House
Scottsdale, AZ, 85259, United States
1.1k from Mayo Clinic Scottsdale center

AC, Balcony, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Hot Tub

4 Bedrooms8 Guests
9.0

Fabulous

2 reviews

$554
Average price / night
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Luxury Estate, Heated Pool, Pickleball Court, More
Luxury Estate, Heated Pool, Pickleball Court, More
Villa
Scottsdale, AZ, USA
2.1k from Mayo Clinic Scottsdale center

Luxury, Accommodations, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings

6 Bedrooms12 Guests
New to Booking
$1586
Average price / night
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Private Pickleball Court Mountain Views Oasis
Private Pickleball Court Mountain Views Oasis
House
Scottsdale, AZ, 85259, United States
1.2k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Dryer, Free Parking, Hot Tub, Internet, Kitchen, Laundry

6 Bedrooms16 Guests
9.4

Superb

3 reviews

$741
Average price / night
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Desert Retreat
Desert Retreat
House
Scottsdale, AZ, USA
2.4k from Mayo Clinic Scottsdale center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Family

1 Bedroom14 Guests
New to Booking
$823
Average price / night
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Beautiful Scottsdale Property
Beautiful Scottsdale Property
House
Scottsdale, AZ, 85259, United States
1.3k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Hot Tub, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
New to Booking
$5518
Average price / night
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Pickleball Cornhole Basketball Court Tons of space at Paradise Heights Retreat
Pickleball Cornhole Basketball Court Tons of space at Paradise Heights Retreat
House
Scottsdale, AZ, USA
2.7k from Mayo Clinic Scottsdale center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Hot tubs

5 Bedrooms14 Guests
New to Booking
$805
Average price / night
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Resort Luxury home in the heart of Scottsdale's McDowell Mountain foothills
Resort Luxury home in the heart of Scottsdale's McDowell Mountain foothills
House
Scottsdale, AZ, 85259, United States
1.5k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms8 Guests
9.8

Exceptional

53 reviews

$242
Average price / night
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5 bd Luxury Oasis Heated Pool Spa Pickle Ball
5 bd Luxury Oasis Heated Pool Spa Pickle Ball
Apartment
Scottsdale, AZ, USA
3.3k from Mayo Clinic Scottsdale center

Apartments, Luxury, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

5 Bedrooms12 Guests
New to Booking
$732
Average price / night
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Hidden Hills Hideaway 30 day minimum stay
Hidden Hills Hideaway 30 day minimum stay
House
Scottsdale, AZ, 85259, United States
1.6k from Mayo Clinic Scottsdale center

AC, Barbecue, Crib, Dryer, Extra Bed, Fireplace, Free Parking, Heater, Hot Tub

4 Bedrooms8 Guests
10.0

Exceptional

5 reviews

$242
Average price / night
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Stunning 5 Bed Luxury Oasis Heated Pool Hot Tub
Stunning 5 Bed Luxury Oasis Heated Pool Hot Tub
Apartment
Scottsdale, AZ, USA
3.4k from Mayo Clinic Scottsdale center

Apartments, Luxury, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

4 Bedrooms10 Guests
New to Booking
$524
Average price / night
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Peak View Paradise: Sports court, Lush grounds & more!
Peak View Paradise: Sports court, Lush grounds & more!
House
Scottsdale, AZ, 85259, United States
1.8k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

6 Bedrooms12 Guests
10.0

Exceptional

4 reviews

$751
Average price / night
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Scottsdale Condo with Balcony and Resort Amenities!
Scottsdale Condo with Balcony and Resort Amenities!
Apartment
Scottsdale, AZ, USA
3.4k from Mayo Clinic Scottsdale center

Apartments, Accommodations, Parking, Spa, Lodgings, Vacation rentals, Hot tubs, Places to stay, Condos

2 Bedrooms6 Guests
New to Booking
$121
Average price / night
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Oasis in the desert - your hiking and biking paradise.
Oasis in the desert - your hiking and biking paradise.
House
Scottsdale, AZ, 85259, United States
1.9k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

3 Bedrooms8 Guests
9.6

Exceptional

4 reviews

$352
Average price / night
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NEW VILLA The Scottsdale Haven w/ heated pool & spa, 7 bed/7 bath
NEW VILLA The Scottsdale Haven w/ heated pool & spa, 7 bed/7 bath
Villa
Scottsdale, AZ, 85259, United States
2.0k from Mayo Clinic Scottsdale center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Hot Tub, Internet, Kitchen

7 Bedrooms14 Guests
10.0

Exceptional

5 reviews

$2360
Average price / night
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Scottsdale Paradise- POOL, Spa, Pickleball/Basketball, Fire Pit & Great HIKING!
Scottsdale Paradise- POOL, Spa, Pickleball/Basketball, Fire Pit & Great HIKING!
House
Scottsdale, AZ, 85259, United States
2.2k from Mayo Clinic Scottsdale center

AC, Arcade, Barbecue, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater

5 Bedrooms14 Guests
10.0

Exceptional

58 reviews

$878
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Family Vacation Rentals in Mayo Clinic Scottsdale.

Where to stay in Mayo Clinic Scottsdale? Best neighborhoods & areas

Mayo Clinic Scottsdale Family Vacation Rentals on the Map

Frequently Asked Questions

You can explore 416 verified family-friendly vacation rentals in Mayo Clinic Scottsdale. These include spacious homes, villas, and condos designed to accommodate families of different sizes.

Prices for family-friendly rentals in Mayo Clinic Scottsdale vary depending on the season, number of bedrooms, and included amenities. Rates typically start from around $121 per night, with larger homes and peak travel periods often costing more.

Many family-friendly rentals in Mayo Clinic Scottsdale offer baby-friendly items such as high chairs, cribs, or pack-and-play options. Availability can vary, so it’s helpful to check the listing details before booking.

Yes, some rentals in Mayo Clinic Scottsdale are well suited for multi-generational stays, offering multiple bedrooms, separate living areas, and enough space for larger groups to stay comfortably together.

For busy travel periods such as school holidays or summer breaks, booking 90 to 120 days in advance is recommended to secure the best options. Availability may be more flexible during quieter times of the year.

Family-friendly rentals in Mayo Clinic Scottsdale often include amenities such as Child Friendly, Pool, and Wellness Facilities. These features help make stays more convenient and enjoyable for both adults and children.

You can use search filters to find rentals that offer features like game rooms, playgrounds, or entertainment areas. Checking property descriptions can also help you identify homes that are well suited for families with children.