Family-Friendly Vacation Rentals in Mayo Clinic Florida, FL: Compare 10+ Sites & Save

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  6.  Mayo Clinic Florida

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456 Best Family Vacation Rentals in Mayo Clinic Florida (Starting from $112)

New Mins to Mayo Clinic Peaceful water views
New Mins to Mayo Clinic Peaceful water views
House
Jacksonville, FL, USA
0.9k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

4 Bedrooms8 Guests
New to Booking
$173
Average price / night
Check Availability
1 Min to Mayo Clinic, 5 to Beach Luxury Suite with 2 King Beds
1 Min to Mayo Clinic, 5 to Beach Luxury Suite with 2 King Beds
Apartment
Jacksonville, FL, 32224, United States
1.0k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Breakfast Available, Dryer, Free Parking, Heater, Internet, Kitchen

2 Bedrooms4 Guests
10.0

Exceptional

1 reviews

$317
Average price / night
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Canal-Front Retreat 4 Mi to Jacksonville Beach!
Canal-Front Retreat 4 Mi to Jacksonville Beach!
House
Jacksonville, FL, USA
0.9k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

1 Bedroom8 Guests
New to Booking
$329
Average price / night
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Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
House
Jacksonville, FL, 32250, United States
1.0k from Mayo Clinic Florida center

AC, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

4 Bedrooms8 Guests
9.4

Superb

78 reviews

$312
Average price / night
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Palm Escape
Palm Escape
House
Jacksonville, FL, USA
1.4k from Mayo Clinic Florida center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

2 Bedrooms10 Guests
New to Booking
$811
Average price / night
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Modern 4BR Jax | Pool Oasis Near Beach | Backyard
Modern 4BR Jax | Pool Oasis Near Beach | Backyard
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms8 Guests
9.0

Fabulous

2 reviews

$394
Average price / night
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5 Star Ultimate King Suite near Mayo
5 Star Ultimate King Suite near Mayo
Apartment
Jacksonville, FL, USA
1.8k from Mayo Clinic Florida center

Parking, Wheelchair Accessible, Balcony/Terrace, Hot Tub, Internet, Air Conditioner, Pool

2 Bedrooms4 Guests
New to Booking
$187
Average price / night
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Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
9.8

Exceptional

38 reviews

$320
Average price / night
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Condo near Jax Beach and Mayo Clinic
Condo near Jax Beach and Mayo Clinic
Apartment
FL, USA
2.2k from Mayo Clinic Florida center

Apartments, Cheap, Accommodations, Pools, Parking, Lodgings, Hot tubs, Places to stay, Family

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$153
Average price / night
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Reel Relaxed | Team Joseph Ellen
Reel Relaxed | Team Joseph Ellen
House
Jacksonville Beach, FL, 32250, United States
1.4k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Dryer, Heater, Hot Tub, Internet, Kitchen, Microwave

3 Bedrooms8 Guests
New to Booking
$443
Average price / night
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Great Condo near Beaches and Mayo Clinic
Great Condo near Beaches and Mayo Clinic
Apartment
Jacksonville, FL, USA
2.2k from Mayo Clinic Florida center

Apartments, Accommodations, Parking, Lodgings, Places to stay, Condos

3 Bedrooms6 Guests
New to Booking
$279
Average price / night
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Comfy Mayo Retreat; Heated Pool,  Close to Beach
Comfy Mayo Retreat; Heated Pool, Close to Beach
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.6

Exceptional

53 reviews

$449
Average price / night
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Be A Nomad - Close to Mayo & Beaches
Be A Nomad - Close to Mayo & Beaches
Apartment
FL, USA
2.3k from Mayo Clinic Florida center

Apartments, Accommodations, Parking, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$219
Average price / night
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Family-Friendly Jax Beach Retreat with Heated Pool
Family-Friendly Jax Beach Retreat with Heated Pool
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet

4 Bedrooms8 Guests
10.0

Exceptional

36 reviews

$495
Average price / night
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Be A Nomad - Spacious Home close to Mayo & Beaches
Be A Nomad - Spacious Home close to Mayo & Beaches
Apartment
Jacksonville, FL, USA
2.3k from Mayo Clinic Florida center

Apartments, Accommodations, Parking, Lodgings, Places to stay

5 Bedrooms10 Guests
New to Booking
$627
Average price / night
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Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
2.2k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
8.4

Very Good

19 reviews

$395
Average price / night
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Courtney Woods Oasis by SkyRun Jacksonville
Courtney Woods Oasis by SkyRun Jacksonville
House
Isle of Palms South, FL, USA
2.9k from Mayo Clinic Florida center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

1 Bedroom6 Guests
New to Booking
$282
Average price / night
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Pet-Friendly Paradise | Pool • Backyard Oasis •3BR
Pet-Friendly Paradise | Pool • Backyard Oasis •3BR
House
Jacksonville, FL, 32246, United States
3.5k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
9.6

Exceptional

9 reviews

$386
Average price / night
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Jacksonville Home, Near Beach and Mayo Clinic!
Jacksonville Home, Near Beach and Mayo Clinic!
House
Jacksonville, FL, USA
2.9k from Mayo Clinic Florida center

Internet, Parking, Pet Friendly, Wheelchair Accessible, Pool, Child Friendly

3 Bedrooms6 Guests
New to Booking
$387
Average price / night
Check Availability
The Ultimate Jacksonville Beach Getaway
The Ultimate Jacksonville Beach Getaway
House
Jacksonville Beach, FL, 32250, United States
3.6k from Mayo Clinic Florida center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
9.8

Exceptional

9 reviews

$553
Average price / night
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Cozy Apt min to Mayo Beaches Free Wi-Fi Coffee Tea
Cozy Apt min to Mayo Beaches Free Wi-Fi Coffee Tea
Apartment
Jacksonville, FL, USA
3.0k from Mayo Clinic Florida center

Apartments, Cheap, Accommodations, Parking, Lodgings, Places to stay, Family, Self-catering

1 Bedroom4 Guests
10.0

Exceptional

2 reviews

$112
Average price / night
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Beach Retreat in Jacksonville: Pet/Family-Friendly
Beach Retreat in Jacksonville: Pet/Family-Friendly
House
Jacksonville Beach, FL, 32250, United States
3.7k from Mayo Clinic Florida center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Kitchen, Laundry

4 Bedrooms12 Guests
8.8

Fabulous

114 reviews

$503
Average price / night
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Taj Duval, Sleeps 14, Saltwater Pool
Taj Duval, Sleeps 14, Saltwater Pool
House
Jacksonville Beach, FL, 32250, United States
3.8k from Mayo Clinic Florida center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen

5 Bedrooms14 Guests
10.0

Exceptional

5 reviews

$1146
Average price / night
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Cute South Jax Beach House near Mayo
Cute South Jax Beach House near Mayo
House
Jacksonville Beach, FL, 32250, United States
3.9k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen

2 Bedrooms6 Guests
9.6

Exceptional

29 reviews

$195
Average price / night
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Entire JAX Beach Bungalow 7 blocks from Ocean
Entire JAX Beach Bungalow 7 blocks from Ocean
House
Jacksonville Beach, FL, 32250, United States
4.0k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms8 Guests
10.0

Exceptional

1 reviews

$275
Average price / night
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Spanish Modern Family Beach Retreat w/ Heated Pool
Spanish Modern Family Beach Retreat w/ Heated Pool
House
Jacksonville Beach, FL, 32250, United States
4.0k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.8

Exceptional

37 reviews

$529
Average price / night
Check Availability
Jax Beach Escape | Pool + Key West Vibe
Jax Beach Escape | Pool + Key West Vibe
House
Jacksonville Beach, FL, 32250, United States
4.1k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Extra Bed, Free Parking, Heater

4 Bedrooms10 Guests
10.0

Exceptional

31 reviews

$1062
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Family Vacation Rentals in Mayo Clinic Florida.

Where to stay in Mayo Clinic Florida? Best neighborhoods & areas

Mayo Clinic Florida Family Vacation Rentals on the Map

Frequently Asked Questions

You can explore 456 verified family-friendly vacation rentals in Mayo Clinic Florida. These include spacious homes, villas, and condos designed to accommodate families of different sizes.

Prices for family-friendly rentals in Mayo Clinic Florida vary depending on the season, number of bedrooms, and included amenities. Rates typically start from around $112 per night, with larger homes and peak travel periods often costing more.

Many family-friendly rentals in Mayo Clinic Florida offer baby-friendly items such as high chairs, cribs, or pack-and-play options. Availability can vary, so it’s helpful to check the listing details before booking.

Yes, some rentals in Mayo Clinic Florida are well suited for multi-generational stays, offering multiple bedrooms, separate living areas, and enough space for larger groups to stay comfortably together.

For busy travel periods such as school holidays or summer breaks, booking 90 to 120 days in advance is recommended to secure the best options. Availability may be more flexible during quieter times of the year.

Family-friendly rentals in Mayo Clinic Florida often include amenities such as Child Friendly, Fireplace/Heating, and Internet. These features help make stays more convenient and enjoyable for both adults and children.

You can use search filters to find rentals that offer features like game rooms, playgrounds, or entertainment areas. Checking property descriptions can also help you identify homes that are well suited for families with children.