Family-Friendly Vacation Rentals in Depew, NY: Compare 10+ Sites & Save

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44 Best Family Vacation Rentals in Depew (Starting from $129)

Sharuns Vacation House
Sharuns Vacation House
Apartment
Depew, NY, USA
1.7k from Depew center

Parking, Internet, Security/Safety, Air Conditioner, Child Friendly

1 Bedroom6 Guests
New to Booking
$198
Average price / night
Check Availability
Quiet suburban home 10 minutes from airport/25 min from Niagara Falls
Quiet suburban home 10 minutes from airport/25 min from Niagara Falls
Apartment
Depew, NY, 14043, United States
0.6k from Depew center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms6 Guests
10.0

Exceptional

16 reviews

$172
Average price / night
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Cozy Duplex Near BUF International Airport
Cozy Duplex Near BUF International Airport
Apartment
Cheektowaga, NY, USA
2.7k from Depew center

Apartments, Cheap, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay, Family, Self-catering

2 Bedrooms5 Guests
9.5

Superb

2 reviews

$129
Average price / night
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Fireman's Park Quarters
Fireman's Park Quarters
House
Depew, NY, 14043, United States
1.1k from Depew center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

6 Bedrooms14 Guests
9.2

Superb

5 reviews

$424
Average price / night
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Luxury Villa
Luxury Villa
Villa
Lancaster, NY, USA
2.9k from Depew center

Luxury, Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

3 Bedrooms5 Guests
8.8

Fabulous

17 reviews

$173
Average price / night
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Buffalo Niagara international airport 2 minutes away from the house
Buffalo Niagara international airport 2 minutes away from the house
Apartment
Cheektowaga, NY, 14225, United States
2.0k from Depew center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms7 Guests
6.8

Good

5 reviews

$339
Average price / night
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Pet-Friendly Lancaster Home 13 Mi to Dtwn Buffalo
Pet-Friendly Lancaster Home 13 Mi to Dtwn Buffalo
House
Lancaster, NY, USA
3.6k from Depew center

Accommodations, Parking, Villas, Vacation homes, Spa, Cottages, Pet-friendly, Lodgings, Places to stay

3 Bedrooms9 Guests
New to Booking
$363
Average price / night
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Luxury Villa\n
Luxury Villa\n
House
Lancaster, NY, 14086, United States
2.6k from Depew center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave, No Smoking

3 Bedrooms5 Guests
9.6

Exceptional

10 reviews

$159
Average price / night
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Spacious Buffalo Home Near Niagara Fall, Bills Stadium, Buffalo Airport
Spacious Buffalo Home Near Niagara Fall, Bills Stadium, Buffalo Airport
House
Depew, NY, USA
3.6k from Depew center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals

3 Bedrooms12 Guests
8.7

Fabulous

12 reviews

$437
Average price / night
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Charming Lancaster Home with Modern Amenities
Charming Lancaster Home with Modern Amenities
House
Lancaster, NY, 14086, United States
2.6k from Depew center

AC, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave

2 Bedrooms4 Guests
9.8

Exceptional

29 reviews

$147
Average price / night
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Dog-Friendly Home about 14 Mi to Highmark Stadium
Dog-Friendly Home about 14 Mi to Highmark Stadium
House
Cheektowaga, NY, USA
4.1k from Depew center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals

3 Bedrooms9 Guests
9.2

Superb

5 reviews

$374
Average price / night
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2UNITModernFarmhouse Sleeps13
2UNITModernFarmhouse Sleeps13
House
Lancaster, NY, 14086, United States
2.9k from Depew center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

5 Bedrooms14 Guests
8.8

Fabulous

11 reviews

$385
Average price / night
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Sweet home
Sweet home
Apartment
Cheektowaga, NY, USA
4.8k from Depew center

Apartments, Cheap, Accommodations, Parking, Lodgings, Places to stay, Self-catering

3 Bedrooms6 Guests
10.0

Exceptional

1 reviews

$225
Average price / night
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9 Mi to Dtwn Buffalo Family Escape with Fenced Yard
9 Mi to Dtwn Buffalo Family Escape with Fenced Yard
House
Cheektowaga, NY, USA
5.4k from Depew center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

3 Bedrooms6 Guests
7.7

Good

3 reviews

$227
Average price / night
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2 Mi to Walden Galleria Apartment with Patio
2 Mi to Walden Galleria Apartment with Patio
Apartment
Buffalo, NY, USA
5.5k from Depew center

Apartments, Accommodations, Parking, Pet-friendly, Lodgings, Places to stay

1 Bedroom2 Guests
New to Booking
$191
Average price / night
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Serene, Renovated 2BR near Airport w/ Yard
Serene, Renovated 2BR near Airport w/ Yard
House
Cheektowaga, NY, 14225, United States
3.8k from Depew center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen

2 Bedrooms5 Guests
10.0

Exceptional

2 reviews

$371
Average price / night
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Niagara Falls, Highmark, Buffalo Vacation House
Niagara Falls, Highmark, Buffalo Vacation House
House
Cheektowaga, NY, USA
6.5k from Depew center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

3 Bedrooms7 Guests
9.5

Superb

2 reviews

$207
Average price / night
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Spacious Buffalo Home Near Niagara Falls/Bills Stadium/Buffalo Airport
Spacious Buffalo Home Near Niagara Falls/Bills Stadium/Buffalo Airport
House
Depew, NY, 14043, United States
4.0k from Depew center

AC, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms12 Guests
9.8

Exceptional

29 reviews

$642
Average price / night
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BEAUTIFUAL 3BR, 1 Bath, FREE PARKING #B, FREE WIFI, FULL KITCHEN, Living room, back yard
BEAUTIFUAL 3BR, 1 Bath, FREE PARKING #B, FREE WIFI, FULL KITCHEN, Living room, back yard
House
Depew, New York, USA
6.5k from Depew center

Air Conditioner, Parking, Pet Friendly, Internet, Child Friendly

3 Bedrooms5 Guests
5.4

Review score

5 reviews

$134
Average price / night
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KING Master En-Suite- BRAND NEW Home- Buffalo's Best Kept Secret!
KING Master En-Suite- BRAND NEW Home- Buffalo's Best Kept Secret!
House
Buffalo, NY, 14225, United States
4.3k from Depew center

AC, Barbecue, Dryer, Extra Bed, Fireplace, Free Parking, Heater, Internet, Kitchen

3 Bedrooms10 Guests
10.0

Exceptional

59 reviews

$290
Average price / night
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Entire Home in Buffalo - 6 Guests 3 Bedroom 1 Bath - Convenient Location - 25min to Niagara Falls
Entire Home in Buffalo - 6 Guests 3 Bedroom 1 Bath - Convenient Location - 25min to Niagara Falls
House
Buffalo, NY, USA
6.7k from Depew center

Cheap, Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Vacation rentals, Places to stay

3 Bedrooms6 Guests
9.4

Superb

29 reviews

$217
Average price / night
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Cayuga Creek Pad
Cayuga Creek Pad
Apartment
Cheektowaga, NY, 14227, United States
6.9k from Depew center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
New to Booking
$279
Average price / night
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Mi casa su casa
Mi casa su casa
House
Cheektowaga, NY, USA
6.7k from Depew center

Accommodations, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Vacation rentals, Places to stay

3 Bedrooms5 Guests
8.3

Very Good

3 reviews

$144
Average price / night
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The Farmhaus - rustic 1800s homestead sleeps 12
The Farmhaus - rustic 1800s homestead sleeps 12
House
Lancaster, NY, 14086, United States
6.9k from Depew center

AC, Arcade, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms12 Guests
10.0

Exceptional

17 reviews

$509
Average price / night
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Quiet Cheektowaga Retreat: 23 Mi to Niagara Falls!
Quiet Cheektowaga Retreat: 23 Mi to Niagara Falls!
House
Cheektowaga, NY, 14215-2905, United States
7.9k from Depew center

AC, Dryer, Extra Bed, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms7 Guests
8.0

Good

5 reviews

$214
Average price / night
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Family Home, King Beds, EV Charger, WFH, AC
Family Home, King Beds, EV Charger, WFH, AC
House
Buffalo, NY, 14226, United States
9.2k from Depew center

AC, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet, Kitchen

4 Bedrooms8 Guests
10.0

Exceptional

6 reviews

$340
Average price / night
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Charming 3-bedroom house with AC and WiFi in beautiful Buffalo
Charming 3-bedroom house with AC and WiFi in beautiful Buffalo
House
Buffalo, NY, 14206, United States
9.2k from Depew center

AC, Dryer, Heater, Internet, Laundry, No Smoking, Washer

3 Bedrooms2 Guests
New to Booking
$295
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Family Vacation Rentals in Depew.

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Frequently Asked Questions

You can explore 44 verified family-friendly vacation rentals in Depew. These include spacious homes, villas, and condos designed to accommodate families of different sizes.

Prices for family-friendly rentals in Depew vary depending on the season, number of bedrooms, and included amenities. Rates typically start from around $129 per night, with larger homes and peak travel periods often costing more.

Many family-friendly rentals in Depew offer baby-friendly items such as high chairs, cribs, or pack-and-play options. Availability can vary, so it’s helpful to check the listing details before booking.

Yes, some rentals in Depew are well suited for multi-generational stays, offering multiple bedrooms, separate living areas, and enough space for larger groups to stay comfortably together.

For busy travel periods such as school holidays or summer breaks, booking 90 to 120 days in advance is recommended to secure the best options. Availability may be more flexible during quieter times of the year.

Family-friendly rentals in Depew often include amenities such as Child Friendly, Internet, and Fireplace/Heating. These features help make stays more convenient and enjoyable for both adults and children.

You can use search filters to find rentals that offer features like game rooms, playgrounds, or entertainment areas. Checking property descriptions can also help you identify homes that are well suited for families with children.