Beach Home Rentals in Mayo Clinic Florida, FL: Compare 10+ Sites & Save

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23 Beach Home Rentals in Mayo Clinic Florida (Starting from $145)

Palm Escape
Palm Escape
House
Jacksonville, FL, USA
1.4k from Mayo Clinic Florida center

Accommodations, Pools, Parking, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

2 Bedrooms10 Guests
New to Booking
$811
Average price / night
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Canal-Front Retreat 4 Mi to Jacksonville Beach!
Canal-Front Retreat 4 Mi to Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
0.9k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Free Parking, Heater, Kitchen, No Smoking, Outdoor Space, Patio

4 Bedrooms8 Guests
2.0

Review score

1 reviews

$305
Average price / night
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Condo near Jax Beach and Mayo Clinic
Condo near Jax Beach and Mayo Clinic
Apartment
FL, USA
2.2k from Mayo Clinic Florida center

Apartments, Cheap, Accommodations, Pools, Parking, Lodgings, Hot tubs, Places to stay, Family

3 Bedrooms6 Guests
10.0

Exceptional

2 reviews

$153
Average price / night
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Manatee House: Private Marsh View Retreat - 1 Mile to Mayo, 5 Miles to Beaches
Manatee House: Private Marsh View Retreat - 1 Mile to Mayo, 5 Miles to Beaches
House
Jacksonville, FL, 32224, United States
0.9k from Mayo Clinic Florida center

AC, Barbecue, Crib, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen

4 Bedrooms12 Guests
10.0

Exceptional

23 reviews

$480
Average price / night
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1 Min to Mayo Clinic, 5 to Beach Luxury Suite with 2 King Beds
1 Min to Mayo Clinic, 5 to Beach Luxury Suite with 2 King Beds
Apartment
Jacksonville, FL, 32224, United States
1.0k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Breakfast Available, Dryer, Free Parking, Heater, Internet, Kitchen

2 Bedrooms4 Guests
10.0

Exceptional

1 reviews

$317
Average price / night
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Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
House
Jacksonville, FL, 32250, United States
1.0k from Mayo Clinic Florida center

AC, Crib, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

4 Bedrooms8 Guests
9.4

Superb

78 reviews

$312
Average price / night
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 Saltwater Pool I Firepits I Large Fenced Backyard I 4 Miles to Beach
Saltwater Pool I Firepits I Large Fenced Backyard I 4 Miles to Beach
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
9.8

Exceptional

14 reviews

$386
Average price / night
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Modern 4BR Jax | Pool Oasis Near Beach | Backyard
Modern 4BR Jax | Pool Oasis Near Beach | Backyard
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms8 Guests
9.0

Fabulous

2 reviews

$394
Average price / night
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Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
House
Jacksonville, FL, 32250, United States
1.2k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
9.8

Exceptional

38 reviews

$320
Average price / night
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SMV Palm Escape Retreat nr Mayo
SMV Palm Escape Retreat nr Mayo
House
Jacksonville, FL, 32250, United States
1.4k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms10 Guests
10.0

Exceptional

2 reviews

$648
Average price / night
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Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
House
Jacksonville, FL, 32250, United States
1.4k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms6 Guests
8.8

Fabulous

5 reviews

$353
Average price / night
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Comfy Mayo Retreat; Heated Pool,  Close to Beach
Comfy Mayo Retreat; Heated Pool, Close to Beach
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.6

Exceptional

53 reviews

$449
Average price / night
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Family-Friendly Jax Beach Retreat with Heated Pool
Family-Friendly Jax Beach Retreat with Heated Pool
House
Jacksonville Beach, FL, 32250, United States
1.6k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Crib, Dryer, Free Parking, Heater, Internet

4 Bedrooms8 Guests
10.0

Exceptional

36 reviews

$495
Average price / night
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Beachy Bungalow: 3BR Home w/ Billiards/grill!
Beachy Bungalow: 3BR Home w/ Billiards/grill!
House
Jacksonville, FL, 32250, United States
2.0k from Mayo Clinic Florida center

AC, Arcade, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

3 Bedrooms8 Guests
10.0

Exceptional

2 reviews

$407
Average price / night
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Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
House
Jacksonville, FL, 32250, United States
2.2k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
8.4

Very Good

19 reviews

$395
Average price / night
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Windsor Wonders - Calm 2BR condo near Mayo
Windsor Wonders - Calm 2BR condo near Mayo
Condo
Jacksonville, FL, 32224, United States
2.2k from Mayo Clinic Florida center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

2 Bedrooms4 Guests
6.0

Review score

1 reviews

$145
Average price / night
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2 Units Boasting 5 bedrooms close to beaches
2 Units Boasting 5 bedrooms close to beaches
House
Jacksonville, FL, 32250, United States
2.2k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Heater, Internet, Kitchen, Microwave, No Smoking

5 Bedrooms10 Guests
New to Booking
$631
Average price / night
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Fun 5 Star Hot Tub/Beaches getaway Near MAYO!
Fun 5 Star Hot Tub/Beaches getaway Near MAYO!
House
Jacksonville, FL, 32250, United States
2.4k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Extra Bed, Heater, Hot Tub, Internet, Kitchen, Laundry

3 Bedrooms6 Guests
7.8

Good

11 reviews

$327
Average price / night
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Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views
House
Jacksonville, FL, 32250, United States
2.4k from Mayo Clinic Florida center

AC, Balcony, Barbecue, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet

3 Bedrooms8 Guests
9.8

Exceptional

109 reviews

$373
Average price / night
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Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
House
Jacksonville, FL, 32224, United States
2.4k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
9.8

Exceptional

6 reviews

$318
Average price / night
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Cozy 3 bedroom condo near Jax beach and Mayo Clinic
Cozy 3 bedroom condo near Jax beach and Mayo Clinic
Condo
Jacksonville, FL, 32224, United States
2.6k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fireplace, Fitness Equipment, Free Parking, Heater, Hot Tub, Internet

3 Bedrooms6 Guests
New to Booking
$161
Average price / night
Check Availability
Peaceful Mayo Condo - 5 Min to Mayo, Pool & Gym, Beach & UNF Nearby
Peaceful Mayo Condo - 5 Min to Mayo, Pool & Gym, Beach & UNF Nearby
Condo
Jacksonville, FL, 32224, United States
2.6k from Mayo Clinic Florida center

AC, Barbecue, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms5 Guests
10.0

Exceptional

6 reviews

$196
Average price / night
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Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
Pet-Friendly Rental, Pool Table, 7 Min to Mayo Clinic!
House
Jacksonville, FL, 32224, United States
2.9k from Mayo Clinic Florida center

AC, Arcade, Balcony, Barbecue, Dryer, Free Parking, Heater, Internet, Kitchen

3 Bedrooms6 Guests
8.0

Good

4 reviews

$291
Average price / night
Check Availability

Pro Tip:
VacationByOwnerRentals aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Beach Rentals in Mayo Clinic Florida.

Where to stay in Mayo Clinic Florida? Best neighborhoods & areas

Mayo Clinic Florida Beach Rentals on the Map

Frequently Asked Questions

You can explore 23 verified beach rentals in Mayo Clinic Florida. Our listings are sourced from trusted booking providers, giving you access to a wide selection of oceanfront homes, seaside condos, and coastal stays—all in one place.

Beach rental prices in Mayo Clinic Florida vary depending on the season, property size, and distance from the shoreline. Rates typically start from around $145 per night, with beachfront properties and peak summer dates often priced higher. Comparing available options can help you find the best fit for your budget.

Many beach rentals in Mayo Clinic Florida offer direct access to the sand or are located within a short walking distance of the shoreline. You can use filters to find properties with beachfront locations, private walkways, or unobstructed ocean views.

Yes, many beach rentals in Mayo Clinic Florida welcome pets. Currently, 12 listings allow pets, although policies may vary by property. It’s also a good idea to check local beach regulations for any restrictions on pets during your stay.

For peak travel periods such as summer holidays or spring break, it’s recommended to book your beach rental 90 to 120 days in advance to secure the best options. During off-peak seasons, you may find more flexibility and availability closer to your travel dates.

Beach rentals in Mayo Clinic Florida often include amenities designed for coastal living, such as View, Ocean View, and Fireplace/Heating. These features help enhance comfort and make it easier to enjoy time by the water.

Some beach rentals provide extras like chairs, umbrellas, or beach gear, but this can vary by property. It’s best to review the amenities section of each listing to confirm what is included and plan accordingly.